Lymph node negative colorectal cancers with isolated tumor deposits should be classified and treated as stage III.

Annals of Surgical Oncology
E J Th BeltH B A C Stockmann

Abstract

The prognostic role of pericolic or perirectal isolated tumor deposits (ITDs) in node-negative colorectal cancer (CRC) patients is unclear. Rules to define ITDs as regional lymph node metastases changed in subsequent editions of the TNM staging without substantial evidence. Aim of this study was to investigate the correlation between ITDs and disease recurrence in stage II and III CRC patients. The medical files of 870 CRC patients were reviewed. Number, size, shape, and location pattern of all ITDs in node-negative patients were examined in relation to involvement of vascular structures and nerves. The correlation between ITDs and the development of recurrent disease was investigated. Disease recurrence was observed in 50.0% of stage II patients with ITDs (13 of 26), compared with 24.4% of stage II patients without ITDs (66 of 270) (P < .01). Disease-free survival of ITD-positive stage II patients was comparable with that of stage III patients. Also within stage III, more recurrences were observed in ITD-positive patients compared with ITD-negative patients (65.1 vs. 39.1%, respectively). No correlation was found between size of ITDs and disease recurrence. More recurrences were seen in patients with irregularly shaped ITDs co...Continue Reading

References

May 1, 1994·Human Pathology·J C HarrisonR Vander Zwaag
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C M BalchJ F Thompson
Jun 20, 2002·Diseases of the Colon and Rectum·C RattoG B Doglietto
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Eva SingletaryFrederick L Greene
Nov 8, 2003·Diseases of the Colon and Rectum·Ashish PrabhudesaiDevinder Kumar
May 3, 2005·Surgery Today·Satoshi TateishiAkinori Iwashita
May 30, 2007·Histopathology·I D Nagtegaal, P Quirke

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Citations

Mar 28, 2012·Epigenomics·Muriel X G DrahtKim M Smits
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Xavier Sagaert
Apr 26, 2014·International Journal of Colorectal Disease·Hannes J LarussonMarkus Zuber
Jan 18, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Purva GopalMary K Washington
Apr 15, 2014·Pathology, Research and Practice·Ayca ErsenSulen Sarioglu
Jan 27, 2011·Cancer Metastasis Reviews·Dieter HölzelJutta Engel
Dec 27, 2011·Cancer Metastasis Reviews·Jutta EngelDieter Hölzel
Dec 30, 2014·Head & Neck·Sulen SariogluAhmet Omer Ikiz
Feb 25, 2014·Molecular Oncology·Muriel X G DrahtManon van Engeland
Oct 5, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M von WinterfeldH Bläker
Aug 20, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·O EstradaX Suñol
Jun 27, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Amy C LordGina Brown
Jun 13, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M BouquotM Svrcek
Aug 8, 2018·Diseases of the Colon and Rectum·Nathalie Wong-ChongLawrence Lee
Aug 8, 2018·Annals of Surgical Oncology·Katelin A MirkinEvangelos Messaris
Oct 31, 2018·Histopathology·Cristina Graham MartínezRachel S van der Post
Oct 29, 2018·Pathology Oncology Research : POR·Merih Guray DurakSulen Sarioglu
Apr 25, 2019·Journal of Surgical Oncology·Leonardo S Lino-SilvaRosa A Salcedo-Hernández
Jun 16, 2019·International Journal of Colorectal Disease·Feng Shen, Xia Hong
Aug 12, 2014·World Journal of Gastroenterology : WJG·Aoife Maguire, Kieran Sheahan
Jul 24, 2018·Oncotarget·Evert van den BroekRemond J A Fijneman
Jul 7, 2011·Diseases of the Colon and Rectum·Osama Al SahafHenry P Redmond
Sep 18, 2014·The American Journal of Surgical Pathology·Ming JinWendy L Frankel
Jul 25, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Miriam K RutegårdKatrine Riklund
Dec 29, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iris D NagtegaalPhilip Quirke
Nov 2, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Miriam K RutegårdKatrine Riklund
Oct 17, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Hillary L SimonDeborah S Keller
May 27, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chongshun LiuYuqiang Li
Jun 17, 2021·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gaetano Gallo
Sep 5, 2021·Virchows Archiv : an International Journal of Pathology·Nelleke P M BrouwerG Brown

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Methods Mentioned

BETA
surgical resection

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SPSS

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