Lymph Node Number Predicts the Efficacy of Adjuvant Chemoradiotherapy in Node-Positive Endometrial Cancer Patients

Diagnostics
Jie LeeMu-Hung Tsai

Abstract

This study aimed to evaluate the value of lymph node (LN) number as a predictor for adjuvant treatment in node-positive endometrial cancer. Data of 441 patients diagnosed with International Federation of Gynaecology and Obstetrics (FIGO) stage IIIC endometrial cancer and who underwent adjuvant chemotherapy alone or chemoradiotherapy between 2009 and 2015 from the Taiwan Cancer Registry were reviewed. The patients were stratified based on the number of positive LN as follows: 1, 2-5, and ≥ 6. The overall survival (OS) was analysed using the Kaplan-Meier method and the Cox proportional hazards model. In multivariable analysis, chemoradiotherapy was independently associated with improved OS (hazard ratio [HR]: 0.62, 95% confidence interval [CI]: 0.43-0.90; p = 0.01) compared with chemotherapy alone. Patients with ≥ 6 positive LNs were associated with a worse OS (HR: 2.22, 95% CI: 1.25-3.95; p = 0.006) and those with 2-5 LNs were not associated with a worse OS (HR: 1.56, 95% CI: 0.94-2.59; p = 0.09) compared to patients with one LN. When stratified based on LN number, chemoradiotherapy was found to significantly improve the 5-year OS of patients with ≥ 6 positive LNs compared to chemotherapy alone (35.9% vs. 70.0%, p < 0.001). No s...Continue Reading

References

Apr 7, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·William Creasman
Jun 15, 2011·Gynecologic Oncology·Pratish H ShahMarcus Randall
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Jul 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anita Giobbie-HurderMeredith M Regan
Sep 11, 2014·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Larissa J LeeAkila N Viswanathan
Jun 8, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Tjalling BosseRemi A Nout
Sep 12, 2015·Lancet·Philippe MoriceEmile Darai
Mar 24, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ellen StellooVincent T H B M Smit
Mar 24, 2017·International Journal of Radiation Oncology, Biology, Physics·Brian BinghamMatthew M Poppe
Sep 17, 2017·Gynecologic Oncology·Pratibha S BinderL Stewart Massad
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jul 1, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jie LeeYu-Jen Chen
May 17, 2019·Journal of Cachexia, Sarcopenia and Muscle·Jie LeeYu-Jen Chen
Jun 13, 2019·The New England Journal of Medicine·Daniela MateiDavid S Miller
Jul 22, 2019·Gynecologic Oncology·Valentina ZanfagninGretchen E Glaser

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