Lymph node-positive bladder cancer treated with radical cystectomy and lymphadenectomy: effect of the level of node positivity.

European Urology
Tatum V TarinB H Bochner

Abstract

The extent of lymphadenectomy needed to optimize oncologic outcomes after radical cystectomy (RC) for patients with regionally advanced bladder cancer (BCa) is unclear. Evaluate the effect of the location of lymph node metastasis on recurrence-free survival (RFS) and cancer-specific survival (CSS) for patients undergoing RC with a mapping pelvic lymph node dissection (PLND). A study of 591 patients undergoing RC with mapping PLND was completed between 2000 and 2010. Median follow-up was 30 mo. RC with mapping PLND. We evaluated the impact of lymph node involvement by location on disease outcomes using the 2010 TNM staging system. Survival estimates were described using Kaplan-Meier methods. Gender, age, pathologic stage, histology, number of positive nodes, location of positive nodes, node density, use of perioperative chemotherapy, and grade were evaluated as predictors of RFS and CSS using multivariate Cox proportional hazard regression. Overall, 114 patients (19%) had lymph node involvement, and 42 patients (7%) had pN3 disease. On multivariate analysis, the number of positive lymph nodes (one or two or more) was significantly associated with increased risk of cancer-specific death (hazard ratio [HR]: 1.9 [95% confidence int...Continue Reading

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References

Aug 29, 2003·The New England Journal of Medicine·H Barton GrossmanE David Crawford
Jun 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harry W HerrE David Crawford
Jul 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·UNKNOWN International Bladder Cancer Nomogram ConsortiumKinjal C Vora
Jan 29, 2008·The Journal of Urology·Nivedita Bhatta DharUrs E Studer

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Citations

Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Benjamin GoldsmithJohn P Christodouleas
Apr 5, 2014·Virchows Archiv : an International Journal of Pathology·Lu WangMaria M Picken
Oct 13, 2015·Clinical & Experimental Metastasis·Shanna A ArnoldAndries Zijlstra
Feb 13, 2015·Future Oncology·Jose A PedrosaLiang Cheng
Jun 1, 2015·World Journal of Urology·Kamran Zargar-ShoshtariPhilippe E Spiess
Sep 23, 2014·Urologic Oncology·Brian HuSiamak Daneshmand
Oct 19, 2013·Expert Review of Anticancer Therapy·Jose A PedrosaLiang Cheng
Aug 31, 2019·Expert Review of Anticancer Therapy·Armando StabileAlberto Briganti
Oct 29, 2019·Journal of Cellular and Molecular Medicine·Rui CaoYe Tian
Feb 28, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chanjuan WangXu Chen
Oct 24, 2018·Frontiers in Surgery·Francesco CattaneoFabrizio Dal Moro
Jul 16, 2013·Current Opinion in Urology·Kamal S Pohar
Jul 5, 2016·International Journal of Urology : Official Journal of the Japanese Urological Association·Yoshinobu KubotaUNKNOWN Committee for Establishment of the Clinical Practice Guideline for the Management of Bladder Cancer and the Japanese Urologi
Apr 8, 2016·Clinical Nuclear Medicine·Wojciech PołomMarcin Matuszewski
Nov 5, 2020·International Journal of Urology : Official Journal of the Japanese Urological Association·Tohru Nakagawa
Feb 10, 2021·Current Oncology Reports·Chanan ReitblatBoris Gershman

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