Lymph node-positive head and neck cancer treated with definitive radiotherapy: can treatment response determine the extent of neck dissection?

Cancer
Anamaria R YeungWilliam M Mendenhall

Abstract

The purpose was to determine if postradiotherapy (RT) neck dissection can be limited to the neck levels of residual adenopathy on post-RT computed tomography (CT). In all, 274 patients with lymph node-positive head and neck squamous cell carcinoma were treated with definitive RT. All patients had a contrast-enhanced CT performed 4 weeks after completing RT to evaluate tumor response. Two hundred eleven heminecks were dissected, either planned pre-RT or because of residual adenopathy on post-RT CT. CT images were reviewed to determine the presence and location of residual adenopathy. Radiographic complete response (rCR) was defined as lymph node size < or =1.5 cm and normal radiographic morphology (no filling defects or calcifications). For each neck level the CT findings were correlated with neck dissection pathology. Correlation of CT nodal response with neck dissection pathology revealed the following negative predictive values of rCR: level I, 100%; level II, 95%; level III, 98%; level IV, 96%; and level V, 96%. A subset analysis was performed on 61 neck levels with initially positive lymph nodes that completely responded to RT that were in a hemineck with residual lymphadenopathy elsewhere in the neck. Correlation of nodal ...Continue Reading

References

May 1, 1986·International Journal of Radiation Oncology, Biology, Physics·W M MendenhallN J Cassisi
Oct 1, 1985·American Journal of Surgery·S SobolN Thong
Aug 12, 1999·The Laryngoscope·A L Kuntz, E A Weymuller
Mar 4, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J CorryL J Peters
Mar 4, 2000·AJR. American Journal of Roentgenology·P M SomA A Mancuso
May 31, 2001·International Journal of Radiation Oncology, Biology, Physics·A W ChanC C Wang
Feb 18, 2004·Archives of Otolaryngology--head & Neck Surgery·Sean LaverickSimon N Rogers
Mar 31, 2004·International Journal of Radiation Oncology, Biology, Physics·David M BrizelRichard L Scher
Nov 24, 2004·Journal of the American College of Surgeons·K Thomas RobbinsAlessandra Rinaldo
Nov 23, 2005·Archives of Otolaryngology--head & Neck Surgery·K Thomas RobbinsFrancisco Vieira
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stanley L LiauwWilliam M Mendenhall
Jun 21, 2006·Archives of Otolaryngology--head & Neck Surgery·Hiroyuki InoueMasahisa Saikawa

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Citations

Dec 11, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Mario López RodríguezFelipe Couñago Lorenzo
Aug 21, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Laura A GoguenDonald J Annino
Sep 20, 2012·The Journal of Laryngology and Otology·J G SandersJ White
Nov 27, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Robert Hermans
May 28, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·R M HermannR M Rödel
Aug 20, 2010·American Journal of Otolaryngology·Audrey WallaceWilliam M Mendenhall
Aug 21, 2009·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·J ThariatM Lapeyre
Nov 26, 2008·Seminars in Radiation Oncology·Miriam N LangoAdam S Garden
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·Bhishamjit S CheraWilliam Mendenhall
Aug 1, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·William R KennedyWilliam M Mendenhall
Jun 15, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·William M MendenhallJohn W Werning
Apr 26, 2011·International Journal of Radiation Oncology, Biology, Physics·Vincent VandecaveyeRobert Hermans
Feb 12, 2011·International Journal of Radiation Oncology, Biology, Physics·Sébastien ClavelPhuc Felix Nguyen-Tan
Feb 13, 2018·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Norhafiza Mat LazimIng Bing Tan

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