PMID: 6984107Nov 2, 1982Paper

Lymph node reactions to cancer

Klinische Wochenschrift
E M Meyer, E Grundmann

Abstract

Histological, histomorphometrical and histochemical data on the response of regional lymph nodes to tumor development, as recorded in experimental and clinical studies, were coordinated and supplemented by recent findings in experimentally induced autochthonous carcinomas in the rat gastrointestinal tract. The attempted correlation led to the definition of several prognostic parameters: 1) The development of germinal centers and the plasmocytic reaction in tumor draining nodes are morphological expressions of active humoral immune responses that may be specifically directed against the tumor. These reactions attain their maximum usually during late stages of tumor development. Their incidence and prognostic significance may vary depending upon the stage and the type of tumor. 2) Sinus histiocytosis is an immunologically nonspecific lymph node response with debatable prognostic significance. 3) Granulomatous sarcoid-like lesions may be understood as signs of an immunologically mediated antitumor response of macrophages activated by T lymphocytes. They are indicative of a favorable prognosis. 4) Paracortical hyperplasia, characterized by an increased population of lymphocytes and eventually immunoblasts, is an expression of an ac...Continue Reading

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Citations

Jun 11, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S McPartlandT Osler
Sep 1, 1986·Cancer Treatment Reviews·H Brincker
Sep 7, 2006·The Prostate·Philippe Olivier GannonFred Saad

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