Lymphadenectomy in Early-Stage Intermediate-/High-Risk Endometrioid Endometrial Cancer: Clinical Characteristics and Outcomes in an Australian Cohort

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Rhonda FarrellPenny M Webb

Abstract

The role of lymphadenectomy (LND) in early-stage endometrial cancer (EC) remains controversial. Previous studies have included low-risk patients and nonendometrioid histologies for which LND may not be beneficial, whereas long-term morbidity after LND is unclear. In a large Australian cohort of women with clinical early-stage intermediate-/high-risk endometrioid EC, we analyzed the association of LND with clinicopathological characteristics, adjuvant treatment, survival, patterns of disease recurrence, and morbidity. From a larger prospective study (Australian National Endometrial Cancer Study), we analyzed data from 328 women with stage IA grade 3 (n = 63), stage IB grade 1 to 3 (n = 160), stage II grade 1 to 3 (n = 71), and stage IIIC1/2 grade 1 to 3 (n = 31/3) endometrioid EC. Overall survival (OS) was estimated using Kaplan-Meier methods. The association of LND with OS was assessed using Cox regression analysis adjusted for age, stage, grade, and adjuvant treatment. The association with risk of recurrent disease was analyzed using logistic regression adjusted for age, stage, and grade. Morbidity data were analyzed using χ2 tests. Median follow-up was 45.8 months. Overall survival at 3 years was 93%. Lymphadenectomy was perf...Continue Reading

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Citations

May 21, 2020·Archives of Gynecology and Obstetrics·Atanas IgnatovHolm Eggemann
Feb 21, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Francesco MultinuAndrea Mariani
Nov 4, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Andreas ObermairMonika Janda

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