PMID: 3747613Sep 1, 1986Paper

Lymphadenectomy in the management of stage I malignant melanoma: a prospective randomized study

Mayo Clinic Proceedings
F H SimE H Soule

Abstract

A prospective randomized study was initiated at our institution in 1972 to determine the efficacy of routine elective lymphadenectomy in localized (stage I) melanoma. Included in the study were 171 patients, 62 of whom had no lymphadenectomy, 55 of whom had delayed lymphadenectomy, and 54 of whom had immediate lymphadenectomy. No significant difference was found among the three treatment groups with respect to survival or metastasis-free survival. Multifactorial analysis indicated that the level of invasion and the thickness of the lesion were the most important prognostic factors, followed by age (60 years or older), site (legs), and tumor type (nodular). A prognostic index based on these variables was highly predictive of metastasis or death. Even when this score was considered, no significant variation was noted among the three treatment groups. More subsequent complications of melanoma, however, occurred in the group with no lymphadenectomy--36 in this group but only 19 in each of the other treatment groups. This finding was not statistically significant but does indicate that a few additional problems may be associated with leaving regional nodes intact. Further studies are needed, and indeed are being conducted, to determ...Continue Reading

References

Sep 1, 1979·Histopathology·V J McGovernG A Farago
Jan 1, 1978·Scandinavian Journal of Plastic and Reconstructive Surgery·J EldhL E Peterson
Sep 22, 1977·The New England Journal of Medicine·U VeronesiN N Trapeznikov
May 1, 1976·The Journal of Dermatologic Surgery·M N Harris, S L Gumport
Oct 1, 1974·American Journal of Surgery·M G Hansen, A B McCarten
Nov 1, 1980·Journal of the American Academy of Dermatology·C M Balch
Dec 1, 1959·Annals of Surgery·S L GUMPORT, H W MEYER
Aug 1, 1962·American Journal of Surgery·L W GUISS, I MACDONALD

❮ Previous
Next ❯

Citations

Jul 1, 1997·Journal of Surgical Oncology·J C Emilia, W Lawrence
Jan 13, 1998·Journal of Surgical Oncology·C P KarakousisJ Trunk
Nov 26, 1998·Seminars in Surgical Oncology·F CafieroL Moresco
Mar 22, 2002·Cancer·Joanne A de HulluAte G J van der Zee
Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·B BiessA Peters
May 12, 2005·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M Möhrle, H Breuninger
May 14, 2005·Der Urologe. Ausg. A·C LoquaiS Grabbe
Jun 16, 2004·Langenbeck's Archives of Surgery·T SchulzeP M Schlag
Aug 19, 2007·International Journal of Clinical Oncology·Arata TsutsumidaToyohiro Honma
Feb 12, 2008·Clinical & Experimental Metastasis·Robert B RebhunJeffrey E Gershenwald
Sep 1, 1990·British Journal of Plastic Surgery·D A HudsonH S King
Jul 1, 1994·Oral Surgery, Oral Medicine, and Oral Pathology·L L PattonA R Baker
Jul 21, 2004·Clinics in Dermatology·Ken K LeeNeil A Swanson
Jan 5, 2001·The Surgical Clinics of North America·J E GervasoniB Cady
Jul 27, 1999·International Journal of Radiation Oncology, Biology, Physics·J CorryJ Ainslie
Aug 29, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·P RutkowskiW Ruka
Apr 29, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C R RossiM Lise
Feb 21, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M BinderH Pehamberger
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M I Ross, D S Reintgen
May 18, 2001·Surgical Oncology·R R White, D S Tyler
Jul 11, 2003·Critical Reviews in Oncology/hematology·Filippo de BraudNatale Cascinelli
Mar 14, 2003·Critical Reviews in Oncology/hematology·Timothy M Pawlik, Vernon K Sondak
Jul 18, 2000·Journal of the American College of Surgeons·A D ChanD L Morton
Mar 5, 1999·Journal of the American College of Surgeons·S H KimD G Coit
Aug 7, 1999·Journal of the American College of Surgeons·D L Morton, A D Chan
May 27, 2008·Actas dermo-sifiliográficas·C MangasC Ferrándiz
Feb 14, 2002·The British Journal of Dermatology·D L L RobertsUNKNOWN Melanoma Study Group
Dec 21, 2000·International Journal of Dermatology·B M Coldiron
Nov 30, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·C C Otley
Mar 7, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·B Coldiron
Sep 3, 2004·The New England Journal of Medicine·Hensin TsaoArthur J Sober
Apr 1, 1988·Annals of Surgery·S M KheirJ S Coon
Jan 1, 1997·Annals of Surgery·D ReintgenM Ross
Oct 9, 2002·Clinical Obstetrics and Gynecology·Edward Podczaski, Joanna Cain
May 16, 2000·Plastic and Reconstructive Surgery·J D WagnerJ J Coleman
Jan 19, 2013·Current Opinion in Oncology·Augustinus P T van der PloegAlexander M M Eggermont

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.