Lymphadenectomy is Unnecessary for Pure Ground-Glass Opacity Pulmonary Nodules

Journal of Clinical Medicine
Yi-Han LinHan-Shui Hsu

Abstract

Lobectomy plus lymph node dissection is the standard treatment of early-stage lung cancer, but the low lymph node metastasis rate with ground-glass opacity (GGO) makes surgeons not perform lymphadenectomy. This study aimed to re-evaluate the lymph node metastasis rate of GGO to help make a clinical judgment. We performed this retrospective study to enroll patients who received lung cancer surgery from 2011 to 2016. Patient characteristics collected included tumor size, solid part size and lymph node metastasis rate. These patients were categorized into pure GGO and part solid GGO groups to undergo analysis. Lymph node metastasis rates were 0%, 3.8% and 6.9% in order of the pure GGO group, the GGO predominant group and the solid predominant group. In the lobectomy patients, the solid predominant group still showed to have the highest lymph node metastasis rate and recurrence rate (8.3% and 10.1%). It is unnecessary to perform lymphadenectomy for patients with pure GGO in view of the 0% lymph node metastasis rate. The higher lymph node metastasis rate in the patients with the solid predominant group, 6.9%, suggested that surgeons should choose a rational lymphadenectomy method according to their GGO property and clinical judgment.

References

Oct 28, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·T NarukeH Asamura
Mar 15, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ajeet GajraStephen L Graziano
Sep 1, 2004·The Annals of Thoracic Surgery·Robert James CerfolioAlfred A Bartolucci
Jan 28, 2005·The Cochrane Database of Systematic Reviews·R ManserD A Campbell
Mar 24, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christophe DoddoliPascal Thomas
Sep 15, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Didier LardinoisWalter Weder
Aug 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Sai-Hong Ignatius Ou, Jason A Zell
Jul 1, 2011·The New England Journal of Medicine·UNKNOWN National Lung Screening Trial Research TeamJoRean D Sicks
Mar 24, 2012·The Annals of Thoracic Surgery·Chukwumere E NwoguMary Reid
Sep 26, 2013·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Jessica L SeidelmanLeslie E Quint
Nov 28, 2013·The Journal of Thoracic and Cardiovascular Surgery·Nasser K AltorkiUNKNOWN I-ELCAP Investigators
Mar 26, 2015·Translational Lung Cancer Research·Hidetaka Uramoto, Fumihiro Tanaka
May 23, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tomohiro HarukiKanji Nagai
Nov 7, 2015·Journal of Thoracic Disease·Takatoshi Aoki
Nov 26, 2015·Clinical Lung Cancer·Paul J SpeicherMark F Berry
Jan 15, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter GoldstrawUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee Advisory Boards and Particip
Aug 19, 2016·Cancer Treatment and Research·Gavitt A WoodardDavid M Jablons
Mar 5, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Aritoshi HattoriKenji Suzuki
Apr 24, 2017·The Annals of Thoracic Surgery·Aritoshi HattoriKenji Suzuki
May 3, 2018·The Journal of Thoracic and Cardiovascular Surgery·Jinlin CaoJian Hu
May 19, 2018·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joan E WalterMatthijs Oudkerk
Jul 28, 2018·Translational Lung Cancer Research·Patricia M de GrootReginald F Munden

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
dissection
biopsy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.