Lymphangiogenesis and angiogenesis during human fetal pancreas development

Vascular Cell
Matthias S RoostSusana M Chuva de Sousa Lopes

Abstract

The complex endocrine and exocrine functionality of the human pancreas depends on an efficient fluid transport through the blood and the lymphatic vascular systems. The lymphatic vasculature has key roles in the physiology of the pancreas and in regulating the immune response, both important for developing successful transplantation and cell-replacement therapies to treat diabetes. However, little is known about how the lymphatic and blood systems develop in humans. Here, we investigated the establishment of these two vascular systems in human pancreas organogenesis in order to understand neovascularization in the context of emerging regenerative therapies. We examined angiogenesis and lymphangiogenesis during human pancreas development between 9 and 22 weeks of gestation (W9-W22) by immunohistochemistry. As early as W9, the peri-pancreatic mesenchyme was populated by CD31-expressing blood vessels as well as LYVE1- and PDPN-expressing lymphatic vessels. The appearance of smooth muscle cell-coated blood vessels in the intra-pancreatic mesenchyme occurred only several weeks later and from W14.5 onwards the islets of Langerhans also became heavily irrigated by blood vessels. In contrast to blood vessels, LYVE1- and PDPN-expressing...Continue Reading

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Citations

Oct 23, 2015·PLoS Genetics·Roderick C SliekerSusana M Chuva de Sousa Lopes
Apr 13, 2021·Endocrine Reviews·John T WalkerAlvin C Powers

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Methods Mentioned

BETA
Fluorescence

Software Mentioned

Amira
Leica Application Suite Advanced Fluorescence LAS AF
Photoshop
ImageJ

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