Lymphangiogenesis is upregulated in kidneys of patients with multiple myeloma

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Julia K ZimmerUyen Huynh-Do

Abstract

Neolymphangiogenesis has recently been demonstrated in transplanted kidneys as well as in chronic interstitial nephritis and IgA nephropathy. However, its significance in kidney disease remains to be defined and a systematic study of renal lymphangiogenesis is warranted. We investigated patients with multiple myeloma (MM) presenting in the great majority with acute renal insufficiency. Controls were allograft kidney donors and patients with renal insufficiency due to acute renal failure (ARF). Lymph vessel length density (LVD) was quantified immunohistochemically by means of antipodoplanin staining followed by computer-assisted stereology. The mean LVD in kidneys of patients with MM (23.19 mm(-2)) was higher when compared with allograft donors (7.42 mm(-2), P = 0.0003) and patients with ARF (6.78 mm(-2), P = 0.0002). The higher LVD was significantly associated with interstitial inflammation, and the newly formed lymph vessels were accompanied by diffuse and nodular interstitial infiltrates composed mainly of CD20(+) B cells and CD27(+) plasma cells. The infiltrates in patients with MM also displayed a higher expression of the B-cell chemoattractant CXCL13. These results demonstrate for the first time that lymphangiogenesis is a...Continue Reading

References

Jan 1, 1989·Urologic Radiology·J T CuttinoJ C Jennette
May 1, 1971·The Journal of Physiology·G H McIntosh, B Morris
Jan 15, 1983·International Journal of Cancer. Journal International Du Cancer·J GerdesH Stein
Aug 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A FreniO Ferraù
Jun 26, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J J MontsenyD Eladari
Feb 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·K MatsuiD Kerjaschki
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HaasS M Meehan
May 4, 2000·The American Journal of Pathology·K PaavonenK Alitalo
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S TakemuraC M Weyand
Oct 12, 2001·Microscopy Research and Technique·J P SleemanP Baumann
Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hajime KuboKari Alitalo
Sep 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P MoriceD Castaigne
Feb 24, 2004·Journal of the American Society of Nephrology : JASN·Dontscho KerjaschkiIngrid Raab
Jul 27, 2004·Annals of Surgery·Sebastian F SchoppmannUNKNOWN Austrian Breast and Colorectal Cancer Study Group
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Michael G AlexandrakisEfstathios Stathopoulos
Feb 19, 2005·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Csaba Galambos, Laurentia Nodit
Sep 3, 2005·The Journal of Clinical Investigation·Dontscho Kerjaschki
Sep 3, 2005·The Journal of Clinical Investigation·Kazuichi MaruyamaJ Wayne Streilein
Sep 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Olivier ThaunatAntonino Nicoletti
Mar 23, 2006·Annual Review of Immunology·Flavius Martin, Andrew C Chan
Jan 19, 2007·Journal of the American Society of Nephrology : JASN·Colin A HutchisonArthur R Bradwell
Jan 27, 2007·The American Journal of Pathology·Florian HellerStephan Segerer
Feb 7, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S StuhtM Mengel
Nov 14, 2007·Arthritis Research & Therapy·Qian ZhangLianping Xing

❮ Previous
Next ❯

Citations

May 25, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Harald SeegerStephan Segerer
Jul 15, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Anca Maria Cimpean, Marius Raica
Oct 23, 2016·Clinical and Experimental Nephrology·Akihiro TsuchimotoKazuhiko Tsuruya
Feb 24, 2017·American Journal of Physiology. Renal Physiology·Sterling C KneedlerBrett M Mitchell

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
S StuhtM Mengel
The American Journal of Pathology
Florian HellerStephan Segerer
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Gang JinYan Tang
© 2021 Meta ULC. All rights reserved