Lymphangioleiomyomatosis: correlation of qualitative and quantitative thin-section CT with pulmonary function tests and assessment of dependence on pleurodesis

Radiology
Nilo A AvilaJoel Moss

Abstract

To explore the relationship between findings at thin-section computed tomography (CT) and pulmonary function tests in lymphangioleiomyomatosis (LAM) and to evaluate the influence of pleurodesis on this relation and the effectiveness of quantitative versus qualitative CT in the assessment of disease severity. Thirty-seven patients with LAM (17 with pleurodesis) underwent CT and pulmonary function tests. The severity of pulmonary cystic involvement was graded qualitatively by two independent readers and measured quantitatively at CT with a thresholding technique. Relationships between findings at CT and pulmonary function tests and the influence of pleurodesis on these findings were assessed with regression analysis and analysis of covariance. Qualitative ratings had good agreement between observers (kappa = 0.75). Quantitative CT had good repeatability and showed significant correlation with the percent predicted forced expiratory volume in 1 second (FEV(1)%) (r = 0.67, P <.001), percent predicted diffusing capacity of lung for carbon monoxide (DLCO%) (r = 0.48, P <.005), percent predicted ratio of residual volume to total lung capacity (RV/TLC%) (r = -0.65, P <.001), and percent predicted TLC (r = 0.34, P <.04). Quantitative CT...Continue Reading

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Citations

Mar 20, 2010·Lymphatic Research and Biology·Angelo M Taveira-DaSilvaJoel Moss
Jun 26, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Mie HayashidaUNKNOWN Respiratory Failure Research Group of the Japanese Ministry of Health, Labor, and Welfare
Mar 2, 2011·European Respiratory Review : an Official Journal of the European Respiratory Society·S HarariJ Moss
Sep 22, 2012·AJR. American Journal of Roentgenology·Jianhua YaoJoel Moss
May 13, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gerald F AbbottJeffrey R Galvin
Apr 25, 2016·Respiratory Investigation·Mie HayashidaUNKNOWN Respiratory Failure Research Group of the Ministry of Health, Labour, and Welfare, Japan
Nov 12, 2016·Expert Opinion on Orphan Drugs·Angelo M Taveira-DaSilva, Joel Moss
Jan 23, 2016·Annals of the American Thoracic Society·Rahul G ArgulaUNKNOWN MILES Study Investigators
Jun 4, 2008·Annals of the New York Academy of Sciences·Connie G GlasgowJoel Moss
Jun 20, 2015·Computational and Mathematical Methods in Medicine·Changli FengRui Liang
Jul 22, 2010·Respiratory Medicine·Connie G GlasgowJoel Moss
Jul 10, 2012·Respiratory Medicine·Sergio HarariJoel Moss
Sep 29, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Olga TorreSergio Harari
Sep 26, 2015·The European Respiratory Journal·Sergio HarariJoel Moss
Mar 13, 2019·Current Pulmonology Reports·Nikolai Wajda, Nishant Gupta
Jul 10, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Wendy K SteagallJoel Moss
Nov 30, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Alicia ChenChi Wan Koo
Sep 4, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Davide EliaSergio Harari
Nov 1, 2006·Cancer Control : Journal of the Moffitt Cancer Center·Angelo M Taveira-DaSilvaJoel Moss
Nov 25, 2017·Expert Review of Respiratory Medicine·Julie NijmehElizabeth P Henske
Sep 30, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Taro KobaYoshikazu Inoue
Apr 24, 2021·Radiology Case Reports·Caterina BenedettoFrancesco Monaco
Aug 31, 2019·Respiratory Medicine·Paola CrivelliFabiano Di Marco

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