Lymphangiosarcoma in the nictitating membrane of a horse

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Christina PuffWolfgang Baumgärtner

Abstract

A 15-year-old Haflinger gelding presented with a mass in the left nictitating membrane. Two biopsies and the excised nictitating membrane were taken at different time points as a result of reoccurrence of the mass and submitted for histopathologic evaluation. The horse was euthanized as a result of poor prognosis following the reoccurrence of the mass after surgical removal. Histologically, the mass consisted of dilated, thin-walled vascular clefts and channels, lined by flattened to cuboidal endothelial cells with moderate cellular pleomorphism. There was up to 1 mitotic figure per high power field. The channels were empty or contained few erythrocytes. In the collagen-rich stroma, few lymphocytes, focal follicular lymphoid aggregations, and marked lymphangiectasia were observed. Immunohistochemically, the neoplastic cells stained positive for vimentin and partially positive for factor VIII-related antigen. Ultrastructural analysis revealed discontinuous endothelial lining vascular channels that partially lacked a basal membrane. Based on the histopathologic, immunohistochemical, and ultrastructural features lymphangiosarcoma was diagnosed.

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Citations

Sep 18, 2014·Journal of the American Veterinary Medical Association·Nicole M ScherrerBrianna C McKenna
Jan 1, 2010·Journal of Comparative Pathology·J JungingerM Hewicker-Trautwein
Aug 21, 2009·Veterinary and Comparative Oncology·M ArendtI M Morgan
Jan 5, 2011·Veterinary Ophthalmology·Rachel L MathesPhillip Anthony Moore
Apr 28, 2011·Veterinary Ophthalmology·Toby L PinnSeth A Koch
Apr 2, 2015·Veterinary Ophthalmology·D Dustin DeesTimothy J Stein
Jan 13, 2015·Veterinary Ophthalmology·Joseph C GerdingAlison B Clode
Dec 9, 2014·The Journal of Veterinary Medical Science·Atigan ThongtharbHiroyuki Nakayama
Nov 8, 2017·Veterinary Ophthalmology·Nicole M ScherrerJulie Engiles
Feb 27, 2015·The Journal of Veterinary Medical Science·Takayuki MineshigeKinji Shirota
Mar 7, 2017·Journal of the American Veterinary Medical Association·Denise Lin, Samuel H Jennings

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Methods Mentioned

BETA
biopsy
biopsies
periodic acid Schiff
electron microscopy

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