Abstract
Substances and macromolecules absorbed by the lymphatic system avoid hepatic first-pass effect and directly enter the blood circulation system. In this study, an anesthetized, mesenteric lymphatic/duodenum-cannulated rat model was used to investigate the role of lymphatic absorption with intraduodenally administered drugs. Quercetin and rutin were administered, respectively, at dosages of 30 and 300 mg/kg intraduodenally. Lymph and plasma samples were collected every 30 min. These samples were prepared by protein precipitation and then analyzed by high-performance liquid chromatography with a photodiode array detector (HPLC-PDA) and verified by LC tandem mass spectrometry (LC-MS/MS). Quercetin was separated by a C18 reversed-phase column, and rutin was separated by a phenyl reverse-phase column. Pharmacokinetic parameters were calculated using the software WinNonlin Standard Edition Version. The maximum concentration (Cmax) of quercetin recovered in lymph, 1.97+/-0.96 microg/mL, was about 5-fold higher than that in plasma, 0.41+/-0.08 microg/mL. The time to reach the highest concentration (Tmax) of quercetin in lymph was 30 min longer than that in plasma. The maximum concentration (Cmax) of rutin recovered in lymph, 0.86+/-0.13...Continue Reading
References
Dec 19, 1975·European Journal of Clinical Pharmacology·R GuglerH J Dengler
Mar 15, 1976·Experientia·G Bauer-Staeb, P Niebes
Jan 1, 1972·Gut·A L Warshaw
Oct 14, 1993·The New England Journal of Medicine·J R Casley-SmithN B Piller
Apr 1, 1996·Journal of Pharmaceutical Sciences·C J PorterW N Charman
Nov 8, 1996·Journal of Chromatography. B, Biomedical Applications·F BressolleM Audran
Jul 3, 1998·The Journal of Nutrition·M K Piskula, J Terao
Aug 4, 1998·FEBS Letters·E L da SilvaJ Terao
Feb 24, 2001·BioFactors·C MorandC Remesy
Jul 4, 2001·Biochemical Pharmacology·W AndlauerP Fürst
Aug 8, 2001·Advanced Drug Delivery Reviews·G A EdwardsW N Charman
Aug 8, 2001·Advanced Drug Delivery Reviews·N HussainA T Florence
Aug 21, 2001·Clinical Pharmacokinetics·J M HarrisM Modi
Jan 24, 2002·Journal of Agricultural and Food Chemistry·Vanessa CrespyChristian Remesy
Mar 7, 2002·Journal of Agricultural and Food Chemistry·Keiko AzumaJunji Terao
Apr 17, 2003·Journal of Agricultural and Food Chemistry·Kayoko ShimoiTakashi Yumoto
Jun 3, 2004·The Journal of Nutrition·Stephanie LesserSiegfried Wolffram
Jan 11, 2005·The American Journal of Clinical Nutrition·Gary Williamson, Claudine Manach
Jul 12, 2005·Annals of Nutrition & Metabolism·Marina Carbonaro, George Grant
Sep 6, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pavel Gershkovich, Amnon Hoffman
Oct 1, 2005·FEBS Letters·Kaeko Murota, Junji Terao
Nov 6, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Arik DahanAmnon Hoffman
Dec 20, 2007·The Journal of Pharmacy and Pharmacology·Gilberto CoppiValentina Iannuccelli
Dec 25, 2007·Advanced Drug Delivery Reviews·Natalie L TrevaskisChristopher J H Porter
Citations
Oct 2, 2013·Archives of Pharmacal Research·Kazunori IwanagaMasawo Kakemi
Nov 5, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Si-Yuan WangTing-Guo Kang
Jun 26, 2013·Expert Opinion on Investigational Drugs·Shrestha SharmaSanjula Baboota
Dec 11, 2014·Cancer Cell International·Aliye Aras PerkAmmad Ahmad Farooqi
Apr 9, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Mei-Ling HouTung-Hu Tsai
May 1, 2015·BMC Cancer·Chen-Hsi HsiehYu-Jen Chen
Apr 8, 2016·Expert Opinion on Drug Metabolism & Toxicology·Thanasekaran JayakumarJoen-Rong Sheu
Jun 29, 2011·Molecular Nutrition & Food Research·María Azorín-OrtuñoJuan C Espín
Sep 29, 2018·Food & Function·Liuqing WangHitoshi Ashida
Dec 15, 2015·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Chia-Hsien ChenTung-Hu Tsai
Oct 28, 2019·Pharmaceutical Nanotechnology·Hanh T H VuArlene McDowell
Jul 30, 2017·Nutrients·Ivana R Sequeira, Sally D Poppitt
Sep 14, 2017·Pharmaceutics·Samaa AlrushaidNeal M Davies
Nov 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wilhelmina Kalt
Sep 24, 2020·Food & Function·Tin-Yun HoChien-Yun Hsiang
Mar 4, 2017·Journal of Chemical Ecology·Kevin D Kohl, M Denise Dearing
May 4, 2017·Drug Delivery and Translational Research·Samaa AlrushaidNeal M Davies
Dec 10, 2020·Phytotherapy Research : PTR·Amir ImaniSolmaz Maleki Dizaj
Oct 16, 2020·Critical Reviews in Food Science and Nutrition·Arakkaveettil Kabeer FarhaHarold Corke
May 20, 2021·Journal of Agricultural and Food Chemistry·Aphichat TrakooncharoenvitTohru Hira
Jul 9, 2010·Journal of Agricultural and Food Chemistry·Rainer Cermak, Siegfried Wolffram
May 27, 2020·ACS Omega·Hua ZhangRong Tsao
Dec 6, 2012·Journal of Agricultural and Food Chemistry·Yung-Jen Tsai, Tung-Hu Tsai