Lymphatic and vascular origin of Kaposi's sarcoma spindle cells during tumor development

International Journal of Cancer. Journal International Du Cancer
Pawan PyakurelP Biberfeld

Abstract

The histogenesis of Kaposi's sarcoma (KS) tumor spindle cells (SC) remains controversial but several immunohistochemical studies favor a lymphatic origin. Twenty KS surgical biopsies were analyzed for the coexpression of LANA, CD34, LYVE-1, D2-40, VEGFR-2, VEGFR3 by using double or triple immunostaining. Most of the SC in both early and late KS expressed the lymphatic markers LYVE-1, D2-40 and VEGFR-3 and the blood vascular endothelial/endothelial precursor cell markers CD34 and endothelial stem cell marker VEGFR-2. All the LANA+ SC in early and late KS were LYVE-1+, but only 75% of these LANA+ cells were CD34(+). The CD34(+)/LANA+ cells increased from early- (68.8%) to late-stage KS (82.2%). However, approximately 18% of the LANA+ SC in early KS were CD34(-) but were LYVE-1+, suggesting that resident lymphatic endothelial cells (LEC) are targeted for primary infection by human herpesvirus-8. This LANA+/LYVE-1+/CD34(-) (resident LEC) cell population clearly decreased during the development of KS from early (18.7%) to late KS (2.9%). Thus, in late stages of KS, most SC were LANA+/CD34(+)/LYVE-1+. However, in both early- and late-stage KS, approximately 18% of the SC were CD34(+)/LANA-/LYVE-1 -- and could represent newly recruite...Continue Reading

References

Jul 1, 1995·Nature Medicine·M SchallingP Biberfeld
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Feb 1, 1995·Cytometry·R J FlorijnA K Raap
Jun 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B EnsoliP Monini
Feb 16, 2002·Acta Oncologica·P L OliveC Aquino-Parsons
Feb 28, 2002·Frontiers in Bioscience : a Journal and Virtual Library·Takashi KomatsuKenneth M Kaye
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Harriette J KahnAlexander Marks
May 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Pawan PyakurelThomas Heiden
Mar 17, 2005·Lymphatic Research and Biology·Lauren Cheung, Stanley G Rockson

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Citations

Apr 12, 2011·Pathology Oncology Research : POR·Nilufer Onak KandemirSukru Oguz Ozdamar
Jun 8, 2013·Cancer Letters·Lu DaiZhiqiang Qin
Jul 7, 2010·Nature Reviews. Clinical Oncology·Klaus-Martin Schulte, Nadia Talat
Jul 12, 2007·Journal of the National Cancer Institute·Renan DuprezAntoine Gessain
May 13, 2008·The American Journal of Surgical Pathology·Kikkeri N NareshMark Bower
Feb 3, 2007·Infectious Agents and Cancer·Pawan PyakurelPeter Biberfeld
Sep 21, 2013·Disease Models & Mechanisms·Victoria W Wen, Karen L MacKenzie
Jan 1, 2012·ISRN AIDS·Louis-Jacques van Bogaert
Apr 27, 2011·Expert Opinion on Pharmacotherapy·Cecilia SgadariBarbara Ensoli
Sep 28, 2013·Expert Opinion on Medical Diagnostics·Milon Amin, Liron Pantanowitz
Feb 9, 2010·Oral Oncology·Velia Ramírez-AmadorGuillermo Martínez-Mata
Feb 29, 2008·The Journal of Investigative Dermatology·Adriano TaddeoSilvia Della Bella
Oct 24, 2007·American Journal of Clinical Pathology·Hongbo YuJason L Hornick
Jul 22, 2008·Journal of the American Academy of Dermatology·Robert A SchwartzLaura Scuderi
Sep 17, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rosamar Eulira Fontes RezendeJosé Luiz Pimenta Módena
Sep 19, 2012·International Journal of Cancer. Journal International Du Cancer·Michael StürzlRamona Jochmann
Oct 1, 2014·Clinical and Experimental Dermatology·E AgiusS R Hoque
Jun 15, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno Augusto Benevenuto de AndradeOslei Paes de Almeida
Jul 23, 2016·Viruses·Pravinkumar PurushothamanSubhash C Verma
Mar 16, 2017·The Journal of Investigative Dermatology·Francesca CalcaterraSilvia Della Bella
Aug 14, 2012·Advances in Anatomic Pathology·Nelson G Ordóñez
Jul 21, 2015·Reviews in Medical Virology·Annie Cristhine Moraes Sousa-SquiavinatoDeilson Elgui De Oliveira
Feb 2, 2019·Nature Reviews. Disease Primers·Ethel CesarmanDenise Whitby
Mar 29, 2020·Seminars in Immunopathology·Jacqueline Fröhlich, Adam Grundhoff
May 23, 2014·Cancer Immunology Research·Benedetta SavinoRaffaella Bonecchi
Nov 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Soo Mi LeeFrank J Slack

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