Lymphatic drainage function and its immunological implications: from dendritic cell homing to vaccine design

Seminars in Immunology
Melody A SwartzSai T Reddy

Abstract

The slow interstitial flow that drains fluid from the blood capillaries into the lymphatic capillaries provides transport of macromolecular nutrients to cells in the interstitium. We discuss herein how this flow also provides continuous access to immune cells residing in the lymph nodes of antigens from self or from pathogens residing in the interstitium. We also address mechanisms by which dendritic cells in the periphery sense interstitial flow to home efficiently into the lymphatics after activation, and how lymphatic endothelium can be activated by this flow, including how it can act as a lymphatic morphoregulator. Further, we present concepts on how interstitial flow can be exploited with biomaterial systems to deliver antigen and adjuvant molecules directly into the lymphatics, to target dendritic cells residing in the lymph nodes rather than in the peripheral tissues, using particles that are small enough to be carried along by flow through the network structure of the interstitium. Finally, we present recent work on lymphatic and lymphoid tissue engineering, including how interstitial flow can be used as a design principle. Thus, an understanding of the physiological processes that govern transport in the interstitium g...Continue Reading

References

Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S R Chary, R K Jain
Aug 1, 1971·The Journal of Cell Biology·L V Leak
Feb 2, 1999·The Journal of Experimental Medicine·J G Cyster
Mar 17, 1999·Annals of Surgery·S A SlavinR K Jain
May 16, 2000·Immunology·C H NielsenR G Leslie
Nov 9, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A LutherJ G Cyster
Dec 29, 2000·Nature·H HemmiS Akira
Mar 17, 2001·Advanced Drug Delivery Reviews·Y Nishioka, H Yoshino
Apr 5, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·D D PatelM S Krangel
Aug 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J TrzewikG W Schmid-Schönbein
Aug 8, 2001·Advanced Drug Delivery Reviews·C Oussoren, G Storm
Feb 1, 2002·Nature Biotechnology·Rong-Fu Wang, Helen Y Wang
Aug 20, 2002·Vaccine·Robert L Hunter
Mar 8, 2003·Circulation Research·Kendrick C Boardman, Melody A Swartz
May 6, 2003·Nature Immunology·Philippe Bousso, Ellen Robey
Jan 8, 2004·Microvascular Research·Shin-ichiro KuroshimaNobuo Inoue
Mar 17, 2004·The Journal of Experimental Medicine·Laura C BonifazRalph M Steinman
Apr 28, 2004·The International Journal of Biochemistry & Cell Biology·Pierre-Yves von der Weid, David C Zawieja
Jun 16, 2004·Journal of Leukocyte Biology·Uwe RitterHeinrich Körner
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Steven R LittleRobert Langer
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Jul 2, 2004·Nature Reviews. Immunology·Richard J Ulevitch
Sep 16, 2004·Journal of Biomedical Materials Research. Part a·Mutsumi Yoshida, Julia E Babensee
Nov 30, 2004·Nature Biotechnology·Sachiko Suematsu, Takeshi Watanabe
Mar 17, 2005·Biomaterials·Xiaojun ZhaoDarrell John Irvine
Mar 18, 2005·Annual Review of Immunology·Jason G Cyster
Jun 7, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Young Jik KwonJean M J Fréchet

❮ Previous
Next ❯

Citations

Feb 8, 2014·Experimental Cell Research·Ellen Berggreen, Helge Wiig
Jul 31, 2013·Angiogenesis·Witold W KilarskiPatrycja Nowak-Sliwinska
Sep 19, 2009·Regenerative Medicine·Samantha Traphagen, Pamela C Yelick
Jan 1, 2009·Journal of Asthma and Allergy·Markus WeckmannBrian Gg Oliver
Oct 21, 2010·Nature Immunology·Jason G Cyster
Sep 21, 2013·Lymphatic Research and Biology·Eric A BridenbaughDavid C Zawieja
Aug 24, 2010·Human Reproduction·Mila VolchekPeter A W Rogers
Jun 5, 2013·Current Opinion in Virology·Franziska ZabelMartin F Bachmann
Jan 22, 2013·Enfermedades infecciosas y microbiología clínica·Alexander Batista-DuharteOliver Pérez
Jul 10, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Sílvia A FerreiraManuel Vilanova
Jan 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yan ZhuangLintao Cai
Aug 9, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anna BershteynDarrell J Irvine
Jun 21, 2011·Advanced Drug Delivery Reviews·Ivy Pal, Joshua D Ramsey
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yu WangXiaoyuan Chen
May 5, 2010·Biochemical and Biophysical Research Communications·Xiao-Mei YangJian-Guo Geng
Oct 6, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunny KumarSamir Mitragotri
Oct 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·John W HickeyHai-Quan Mao
Oct 23, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jardin LeleuxKrishnendu Roy
Jul 15, 2009·Immunological Reviews·David G Jackson
Jan 5, 2011·Immunological Reviews·Heather D HickmanJonathan W Yewdell
Aug 24, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Helge WiigRaghu Kalluri
Aug 24, 2013·International Immunopharmacology·Alexander Batista-DuharteOliver Pérez
Apr 14, 2015·Nanomedicine·Anushree SethYong Taik Lim
Jul 29, 2008·Drug Discovery Today·Jean-Pierre Y Scheerlinck, Deanne L V Greenwood
Jan 13, 2012·Journal of the Royal Society, Interface·K N Margaris, R A Black
Mar 7, 2017·Immune Network·Ki-Wook Kim, Joo-Hye Song
Sep 14, 2013·Journal of Dental Research·E Berggreen, H Wiig
Jan 3, 2019·Journal of Drug Targeting·Ana Sara CordeiroMaría José Alonso
Sep 11, 2010·The American Journal of Surgical Pathology·Melissa P PulitzerKlaus Busam
Jun 21, 2014·Nature Reviews. Immunology·Balthasar A HeestersMichael C Carroll
Dec 1, 2011·Cardiovascular Engineering and Technology·Matthew E Nipper, J Brandon Dixon

❮ Previous
Next ❯

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