Lymphatic drainage of the CNS: effects of lymphatic diversion/ligation on CSF protein transport to plasma

The American Journal of Physiology
M BoultonM G Johnston

Abstract

The plasma recovery of an intraventricularly administered protein was compared before and after lymph diversion/ligation in the same conscious sheep to determine the relative roles of arachnoid villi and lymphatics in the clearance of a cerebral spinal fluid tracer. 125I-human serum albumin was injected into both lateral ventricles, and venous blood was sampled. One day later, multiple cervical vessels and the thoracic duct were cannulated for lymph collection. Uncannulated vessels were ligated. The experiment was repeated with 131I-human serum albumin as the tracer. Before lymph diversion/ligation, the time-averaged tracer transport into the plasma was 6.4 +/- 1.0%/h, with an average 6-h plasma recovery of 38.2 +/- 5.7% (percentage of injected dose). After lymph diversion/ligation, the values dropped to 2.9 +/- 0.5%/h and 17.7 +/- 2.7%, respectively. The collected lymph contained 8.7 +/- 2.6% of the tracer. No significant differences were observed in sham-operated animals. In conclusion, extracranial lymphatic vessels in sheep transport approximately one-half of the protein tracer from the cerebral spinal fluid compartment into plasma.

Citations

Sep 14, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C PapaiconomouM Johnston
Nov 16, 2002·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·M Johnston, C Papaiconomou
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J B DicksteinJ B Hay
May 16, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R MollanjiM G Johnston
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gurjit NagraMiles Johnston
Feb 29, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G NagraM Johnston
Apr 11, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R MollanjiM Johnston
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R Bozanovic-SosicM G Johnston
Sep 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R MollanjiM Johnston
Sep 18, 2021·Biomarker Research·Daniel B HierDonald C Wunsch

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