Lymphatic filariasis and Brugia timori: prospects for elimination

Trends in Parasitology
Peter FischerRick M Maizels

Abstract

Brugia timori is a pathogenic filarial nematode of humans, replacing the closely related species Brugia malayi on some islands in eastern Indonesia. Recent studies on Alor island show that, locally, B. timori is still of great public health importance, causing mainly acute filarial fever and chronic lymphedema. PCR-based assays to detect parasite DNA, in addition to assays for detecting specific antibodies that have been originally developed for B. malayi, can be used efficiently as diagnostic tools for B. timori. In the framework of the Global Program to Eliminate Lymphatic Filariasis, a single annual dose of diethylcarbamazine, in combination with albendazole, was found to reduce the prevalence and density of microfilaraemia persistently. Therefore, elimination of B. timori appears to be achievable.

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Citations

May 9, 2012·Parasitology Research· LalrotluangaGurusubramanian Guruswami
Dec 15, 2012·Parasitology Research·Paul E Simonsen, Mbutolwe E Mwakitalu
Nov 28, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S ManguinT Chareonviriyaphap
Feb 11, 2005·Annals of Tropical Medicine and Parasitology·P FischerN Rahmah
Dec 19, 2018·The American Journal of Tropical Medicine and Hygiene·Taniawati SupaliPeter U Fischer
Jun 20, 2008·Health & Social Care in the Community·Hilary Arksey, Marjolein Morée
Aug 26, 2010·Population and Development Review·Ron Lesthaeghe
Nov 21, 2007·Parasitology Research·Ephantus J MuturiRobert J Novak
Apr 7, 2006·Expert Review of Anti-infective Therapy·Achim Hoerauf
Jul 27, 2017·Tropical Medicine and Infectious Disease·Benjamin F R DicksonWilliam J McBride
Jul 26, 2019·Journal of Clinical Microbiology·Blaine A MathisonBobbi S Pritt
Sep 20, 2019·The Korean Journal of Parasitology·Juyoung Lee, Jae-Sook Ryu
Dec 23, 2020·International Health·D Ramaiah Kapa, Ahmed Jamsheed Mohamed

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