Lymphatic invasion according to D2-40 immunostaining is a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus

Pathology International
Yasuka MiyakuniSatoru Takeda

Abstract

In endometrioid adenocarcinoma of the uterine corpus, nodal metastasis is related to prognosis. D2-40 immunostaining has recently been used to detect lymphatic invasion, but a study of D2-40 immunostaining for endometrioid adenocarcinoma of the uterine corpus has not been published. Therefore, as a predictor of nodal metastasis in endometrioid adenocarcinoma of the uterine corpus, the detection of lymphatic invasion on D2-40 immunostaining and lymphovascular invasion on HE stain was compared. A total of 104 cases of invasive endometrioid adenocarcinoma of the uterine corpus, in which the tumor was located in the uterus, were examined on immunohistochemistry using D2-40. In 20 cases there was lymphatic invasion according to D2-40 immunostaining, and the lymphatic invasion was well detected on D2-40 immunostaining. Nodal metastasis was present in 11 cases. Both lymphatic invasion on D2-40 immunostaining and lymphovascular invasion on HE stain were statistically correlated with nodal metastasis, but the evaluation of lymphatic invasion on D2-40 immunostaining was more accurate than detection of lymphovascular invasion using HE stain, in the current and previous studies, for the prediction of nodal metastasis. In conclusion, lympha...Continue Reading

References

Sep 10, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Harriette J Kahn, Alexander Marks
Feb 22, 2005·Gynecologic Oncology·Justine M BriëtHans W Nijman
Jul 2, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Evangelos EvangelouThomas A Trikalinos
May 4, 2006·British Journal of Cancer·G G Van den EyndenE A Van Marck
Jan 9, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Angel Arnaout-AlkarainAlexander N Marks

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Citations

Oct 12, 2012·Reviews in Endocrine & Metabolic Disorders·Jane E Girling, Peter A W Rogers
Feb 14, 2012·Pathology, Research and Practice·Masayuki TsunekiTakashi Saku
Oct 20, 2009·Journal of the American Academy of Dermatology·Matthew PetittBrent Kelly

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