Lymphatic Invasion Might Be Considered as an Upstaging Factor in N0 and N1 Gastric Cancer

Journal of Clinical Medicine
Won Hyuk ChoiWoon Geon Shin

Abstract

(Background) The aim of this study was to investigate the prognostic impact of lymphatic invasion in gastric cancer, focusing on survival differences between N stage groups. (Methods) A total of 398 consecutive patients who underwent curative gastrectomy for primary gastric adenocarcinoma from January 2006 to December 2015 were analyzed retrospectively using data from a prospectively collected registry database. We compared various clinicopathological features and survival differences between lymphatic invasion-positive and -negative groups. (Results) Of the 398 patients, 141 (35.4%) showed lymphatic invasion. The lymphatic invasion-positive subgroup had poorer prognosis than the lymphatic invasion-negative subgroup in N0 (five-year survival rate: 87.8% vs. 73.6%, p = 0.048) and N1 (87.2% vs. 50%, p = 0.007) stage patients. The odds ratio (OR) of lymphatic invasion to five-year survival rate was 2.078 (95% confidence interval (CI), 1.103-3.916; p = 0.024). The presence of lymphatic invasion had worse effect on survival than age (OR, 1.807; 95% CI, 1.024-2.242; p = 0.029) or tumor depth (OR, 1.286; 95% CI, 1.078-1.897; p = 0.013) in N0 and N1 stage patients. The overall survival of patients with lymphatic invasion was not differ...Continue Reading

References

Feb 15, 2000·The British Journal of Surgery·C H YooJ S Min
Oct 2, 2001·The British Journal of Surgery·H K LeeJ P Kim
Apr 17, 2002·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Jin-Pok KimHan-Kwang Yang
Sep 28, 2007·Annals of Surgical Oncology·Keun Won RyuJae-Moon Bae
Apr 23, 2009·Journal of Gastroenterology and Hepatology·Itaru KamataToshiharu Ishii
May 29, 2009·Journal of Surgical Oncology·Daisuke IchikawaEigo Otsuji
Nov 3, 2009·Surgery·Chikara KunisakiMasazumiu Takahashi
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
May 17, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·UNKNOWN Japanese Gastric Cancer Association
Jul 1, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Enyi LiuHairong Jiang
Jul 25, 2012·World Journal of Gastroenterology : WJG·Chun-Yan DuYing-Qiang Shi
Jan 24, 2013·Cancer Medicine·Koji MatsuoLynda D Roman
Apr 7, 2017·Respirology : Official Journal of the Asian Pacific Society of Respirology·Youngkyu MoonSook Whan Sung
Jul 16, 2017·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Zorica ŠpirićŽivka Eri

❮ Previous
Next ❯

Citations

Apr 2, 2021·The Journal of Pharmacy and Pharmacology·Lei JiangZhensheng Qin

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.