PMID: 9545576May 16, 1998Paper

Lymphatic uptake and biodistribution of liposomes after subcutaneous injection . IV. Fate of liposomes in regional lymph nodes

Biochimica Et Biophysica Acta
C OussorenG Storm

Abstract

The ability of clodronate-containing liposomes to deplete lymph nodes of macrophages was used as a tool to investigate the fate of liposomes in regional lymph nodes after subcutaneous (s.c.) administration. Reduced lymph node localization of liposomes in macrophage-depleted lymph nodes confirmed that phagocytosis by macrophages plays an important role in lymph node retention of liposomes. Depletion of macrophages had less effect on lymph node localization of small liposomes than on the lymph node localization of large liposomes. Inclusion of distearoylphosphatidylethanolamine (DSPE)-poly(ethyleneglycol) (PEG-PE) into the liposomes, which is known to oppose macrophage uptake, did not affect lymph node localization in macrophage-depleted or control lymph nodes. We conclude that PEG-liposomes retained by lymph nodes are also taken up by lymph node macrophages. Morphological observations visualizing the uptake of PEG-liposomes by lymph node macrophages support this conclusion.

References

Oct 19, 1979·Biochimica Et Biophysica Acta·F OlsonD Papahadjopoulos
May 10, 1989·Biochimica Et Biophysica Acta·G LázárG L Scherphof
Jul 13, 1983·Biochimica Et Biophysica Acta·K HongD Papahadjopoulos
Jan 1, 1994·Journal of Drug Targeting·A M Buiting, N Van Rooijen
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders

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Citations

Jun 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·L Harivardhan ReddyR S R Murthy
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·P LavermanO C Boerman
Mar 17, 2001·Advanced Drug Delivery Reviews·Y Nishioka, H Yoshino
Aug 8, 2001·Advanced Drug Delivery Reviews·C Oussoren, G Storm
Jun 11, 1999·International Journal of Pharmaceutics·C Oussoren, G Storm
May 18, 2001·Journal of Pharmaceutical Sciences·T Lian, R J Ho
Dec 18, 2013·Journal of Pharmaceutical Sciences·John C KraftRodney J Y Ho
Jun 21, 2011·Advanced Drug Delivery Reviews·Lisa M Kaminskas, Christopher J H Porter
May 19, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·George K MutwiriLorne A Babiuk
Aug 19, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Lisa M KaminskasChristopher Jh Porter
Feb 24, 2009·Advanced Drug Delivery Reviews·Kaley D WilsonYing K Tam
Oct 17, 2015·Nature Reviews. Drug Discovery·Natalie L TrevaskisChristopher J H Porter
Sep 24, 2004·Diabetes/metabolism Research and Reviews·P MoriguchiL S Sudo-Hayashi
Feb 27, 2003·Journal of Liposome Research·Nico van Rooijen, Esther van Kesteren-Hendrikx
Feb 8, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Pontus KjellmanSven-Erik Strand
Feb 9, 2010·Journal of Drug Targeting·Linglin FengWeiyue Lu
Oct 29, 2000·Cytokine·M E NevilleR J Robb
May 26, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Naomi BenneBram Slütter
Mar 31, 2010·Pharmaceutics·Malou Henriksen-LaceyYvonne Perrie
Aug 4, 2018·Archives of Pharmacal Research·Seung-Hyun JeongYong-Bok Lee
Nov 28, 2017·Current Opinion in Organ Transplantation·Baharak BahmaniReza Abdi
Mar 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christelle CapiniRanjeny Thomas
Apr 15, 2016·Therapeutic Delivery·Andreas M ReichmuthDaniel Blankschtein
Dec 30, 2016·Future Science OA·Pontus KjellmanRené In 't Zandt
Sep 24, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masaki GomiHidetaka Akita
Mar 15, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sai T ReddyMelody A Swartz

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