Lymphatics in the liver

Current Opinion in Immunology
Masatake Tanaka, Yasuko Iwakiri

Abstract

The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma. Despite its apparent relevance in healthy and diseased livers as these and other observations indicate, the hepatic lymphatic system has been poorly studied. With knowledge of the lymphatic system in other organs and tissues incorporated, this review article addresses the current knowledge of the hepatic lymphatic system and the potential role of lymphatic endothelial cells in the health and the disease of the liver and concludes with a brief description on future directions of the study of the hepatic lymphatic system.

Citations

Sep 10, 2020·Seminars in Liver Disease·April O'BrienShannon Glaser
Aug 8, 2019·Animals : an Open Access Journal From MDPI·Yanyan ChenShanyuan Chen
Sep 6, 2020·Science Immunology·Xenia Ficht, Matteo Iannacone
Sep 22, 2020·Clinical and Molecular Hepatology·Reiichiro Kondo, Yasuko Iwakiri
Dec 15, 2020·Scientific Reports·Nicola C FrenkelJeroen Hagendoorn
Dec 29, 2020·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masashi HirookaYoichi Hiasa
Apr 8, 2020·ACS Pharmacology & Translational Science·Claire E Trincot, Kathleen M Caron
Oct 12, 2020·The American Journal of Pathology·Peter BalukDonald M McDonald

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