PMID: 6539868Jul 1, 1984Paper

Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects

Neurology
S L HauserH L Weiner

Abstract

We studied the effects of lymphocytapheresis in five patients with chronic progressive MS. Ten lymphocytapheresis treatments were given in 2 weeks, followed by 1 treatment every 2 weeks for 2 to 6 months. Four of five patients had a fall in the circulating lymphocyte count during the initial treatment, and in three patients a modest lymphopenia was sustained with maintenance therapy. In patients with abnormal T4:T8 ratios, no improvement in the T4:T8 ratio occurred. There was no apparent clinical effect in this pilot study.

Citations

Apr 15, 2000·Journal of Clinical Apheresis·R Weinstein
Jan 1, 1993·Journal of Clinical Apheresis·D CiavarellaB C McLeod
Mar 1, 1985·Italian Journal of Neurological Sciences·A GhezziC L Cazzullo
Feb 1, 1986·Italian Journal of Neurological Sciences·A GhezziC L Cazzullo
Feb 1, 1994·Italian Journal of Neurological Sciences·A UccelliG L Mancardi
Apr 29, 1998·Immunology and Cell Biology·K Bashir, J N Whitaker
May 5, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·J SuemitsuY Yamashita
Jan 1, 1984·Annals of the New York Academy of Sciences·H L WeinerD M Dawson
Mar 1, 1988·Annals of Neurology·H L Weiner, D A Hafler
May 25, 2004·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hidenori MatsuoNoritoshi Shibuya
Oct 18, 2000·The Cochrane Database of Systematic Reviews·G FilippiniL Candelise
Dec 11, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Shunya NakaneNoritoshi Shibuya

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