Lymphocyte adhesion and interactions with biomaterial adherent macrophages and foreign body giant cells.

Journal of Biomedical Materials Research. Part a
David T ChangJames M Anderson

Abstract

To characterize the effects of adherent macrophages and biomaterial surface chemistries on lymphocyte adhesion and activation, lymphocytes were co-cultured with monocytes alone and together, directly and separated by a porous membrane transwell on hydrophobic, hydrophilic/neutral, hydrophilic/anionic, and hydrophilic/cationic biomaterial surfaces. Surface adherent cells were quantitatively analyzed after 3 days utilizing immunofluorescence and phase contrast imaging. After periods of 3, 7, and 10 days, secreted interferon-gamma (IFN-gamma) was quantified by ELISA. Limited direct biomaterial-adherent lymphocytes were identified regardless of the presence of macrophages or foreign body giant cells (FBGC). The majority of adherent lymphocytes, which were T cells (>95%) rather than natural killer cells, predominantly interacted with adherent macrophages and FBGCs; greater than 90% were interacting on surfaces with higher levels of adherent macrophages and FBGCs and greater than 55% were interacting on surfaces with lower levels of macrophages and FBGCs. The hydrophilic/anionic surface promoted higher levels of macrophage- and FBGC-adherent lymphocytes but was nonselective for lymphocyte subtype interactions. The hydrophilic/neutral...Continue Reading

References

Sep 1, 1986·Journal of Biomedical Materials Research·M YokoyamaY Sakurai
Jan 1, 1994·Journal of Biomaterials Science. Polymer Edition·T GrothG Altankov
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A K McNally, J M Anderson
Jun 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M P GrootemanA J van Houte
Mar 1, 1996·Clinical and Diagnostic Laboratory Immunology·W E KatzinM A Klein
Sep 14, 2000·Journal of Biomedical Materials Research·Y NakayamaT Matsuda
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Mar 15, 2003·Immunologic Research·Yuko J MiyamotoBradley W McIntyre
Apr 22, 2003·Journal of Cellular Physiology·M A Santana, Y Rosenstein
Nov 6, 2003·Journal of Cell Science·Nancy HoggAlison McDowall
Mar 23, 2004·Current Drug Targets. Inflammation and Allergy·Claudia MonacoEwa Paleolog
Nov 9, 2004·Trends in Immunology·Alberto MantovaniMassimo Locati
Jun 11, 2005·Journal of Biomedical Materials Research. Part a·William G BrodbeckJames M Anderson
Aug 8, 2006·Tissue Engineering·Daniël T LuttikhuizenMarja J A Van Luyn
Aug 29, 2006·Seminars in Cancer Biology·William H D Hallett, William J Murphy
May 16, 2007·Journal of Biomedical Materials Research. Part a·Jacqueline A JonesJames M Anderson
May 17, 2007·Current Medicinal Chemistry·S G MaherA M Gamero
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
Jan 8, 2008·Plastic and Reconstructive Surgery·Lukas PrantlStephan Schreml
Jan 18, 2008·Journal of Biomedical Materials Research. Part a·David T ChangJames M Anderson
Apr 26, 2008·Journal of Biomedical Materials Research. Part a·David T ChangJames M Anderson

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Citations

Feb 27, 2014·Tissue Engineering. Part C, Methods·Mariana B OliveiraJoão F Mano
Jan 29, 2011·Seminars in Immunopathology·James M Anderson, Amy K McNally
Feb 24, 2015·The Journal of Oral Implantology·Marco MorraMarco Bellanda
May 4, 2016·Trends in Biotechnology·Ajaykumar VishwakarmaAli Khademhosseini
Jul 12, 2018·Advanced Healthcare Materials·Francesca TaraballiEnnio Tasciotti
Jan 30, 2013·Macromolecular Bioscience·Sílvia GomesDavid L Kaplan
Feb 6, 2019·International Journal of Molecular Sciences·Erminia MarianiLia Pulsatelli
May 22, 2021·Frontiers in Bioengineering and Biotechnology·Fu WeiQuanyi Guo

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