PMID: 9178725Jun 1, 1997Paper

Lymphocyte and monocyte subset changes during cardiopulmonary bypass: effects of aging and gender

The Journal of Laboratory and Clinical Medicine
C S RinderB R Smith

Abstract

Complications of cardiopulmonary bypass (CPB) may be associated with either immune suppression or immune activation, but the specific effects of CPB on many lymphocyte and monocyte subsets are unclear. In addition, the increasing age of patients undergoing cardiac surgery raises the possibility of even greater effects on the immune system in elderly patients. We measured immunophenotypic alterations of circulating lymphocytes and monocytes after CPB in male and female cardiac surgery patients who were either younger than 60 or older than 75 years of age. The total lymphocyte counts in all patients decreased postoperatively; older patients had significantly lower counts at all time points. The absolute decline was greatest among T cells and particularly CD4+ T cells, which reached an average nadir of 251 cells/microl on postoperative day 1 in the older patients. The percentages of CD8+, CD4+CD45RA+, and CD4+CD45RO+ T cells did not change significantly, whereas the percentages of B cells and natural killer cells increased. Both T and B lymphocytes and monocytes showed evidence of activation, with increased percentages of CD3+HLADr+, CD3+IL2R+, and CD19+CD23+ lymphocytes and increased expression of CD11b on monocytes. By contrast,...Continue Reading

References

Dec 1, 1975·American Journal of Surgery·P F GrmoljezG C Kaiser
Apr 1, 1992·Transfusion Medicine Reviews·J V Linden, P T Pisciotto
Feb 1, 1990·The New England Journal of Medicine·K E AndersonR B Stead
Aug 2, 1990·The New England Journal of Medicine·K C Anderson, H J Weinstein
Feb 1, 1990·The British Journal of Surgery·M J HershmanH C Polk
Apr 1, 1989·The Journal of Infectious Diseases·R J WallaceR K Selander
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·E FosseS Sunde
Feb 1, 1988·The Journal of Experimental Medicine·S B Clarkson, P A Ory
Sep 1, 1987·The Annals of Thoracic Surgery·H IdeK Asano
Mar 1, 1985·The Annals of Thoracic Surgery·H van Velzen-BladR E Ballieux
Oct 1, 1984·The Annals of Thoracic Surgery·M G SarrT R Townsend
Apr 1, 1981·The Annals of Thoracic Surgery·J A RothD L Morton
Oct 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·J PerttiläO Vainio
Feb 1, 1993·The Annals of Thoracic Surgery·J ButlerS Westaby
Feb 1, 1993·American Journal of Surgery·W G Cheadle

❮ Previous
Next ❯

Citations

Jun 7, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Tetsuro SanoHisataka Yasui
Nov 4, 2000·Surgery Today·T YamaguchiT Misaki
Apr 24, 2009·Journal of Clinical Immunology·Philip A EfronAlan W Hemming
Jun 6, 2003·The New England Journal of Medicine·Leonard H CalabreseRobert Zackin
Mar 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Firdaus S Dhabhar
Dec 19, 2012·Clinics in Dermatology·Firdaus S Dhabhar
Aug 28, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Antonio Hernandez ConteRoya Yumul
Nov 21, 2007·American Journal of Clinical Pathology·Jiann-Horng YehHou-Chang Chiu
Oct 28, 2008·The Journal of Surgical Research·Axel FrankeAndreas Markewitz
May 7, 2014·Immunologic Research·Firdaus S Dhabhar
Jun 1, 1997·The Journal of Laboratory and Clinical Medicine·P K Peterson
Nov 8, 2014·Surgery Research and Practice·Maja-Theresa DieterlenMarkus J Barten
Nov 3, 2004·Hepatology Research : the Official Journal of the Japan Society of Hepatology·M IshikawaH Miki
Feb 8, 2003·Stroke; a Journal of Cerebral Circulation·Joseph P MathewUNKNOWN Cardiothoracic Anesthesiology Research Endeavors Investigators of the Duke Heart Center
Jul 16, 1999·The American Journal of Gastroenterology·J F Trotter
Jun 25, 2005·Anesthesia and Analgesia·Manuel L FontesUNKNOWN Multicenter Study of Perioperative Ischemia (McSPI) Research Group
Jun 21, 2014·Journal of Cardiovascular Pharmacology·Berber KapiteinAd J J C Bogers
Apr 30, 2003·Cytometry. Part B, Clinical Cytometry·Jens-Christian StrohmeyerHans-Dieter Volk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.