Lymphocyte-C-reactive Protein Ratio as Promising New Marker for Predicting Surgical and Oncological Outcomes in Colorectal Cancer

Annals of Surgery
Yoshinaga OkugawaMasato Kusunoki

Abstract

MINI: In the present study, we systemically and comprehensively evaluated the prognostic significance of a combination of inflammatory factors using preoperative blood examination, and focused on the potential feasibility of our newly developed lymphocyte-CRP ratio (LCR) as a prognostic biomarker in CRC patients. We have firstly identified that a combination of lymphocytic counts along with CRP levels, which we defined as LCR, is a more reliable indicator of poor prognosis compared with other combinations of inflammatory markers, in CRC patients. Furthermore, preoperative LCR could also identify CRC patients who are at higher risk for postoperative infectious complications. Systemic inflammation via host-tumor interactions is currently recognized as a hallmark of cancer. The aim of this study was to evaluate the prognostic value of various combinations of inflammatory factors using preoperative blood, and to assess the clinical significance of our newly developed inflammatory score in colorectal cancer (CRC) patients. In total 477 CRC patients from the discovery and validation cohorts were enrolled in this study. We assessed the predictive impact for recurrence using a combination of nine inflammatory markers in the discovery s...Continue Reading

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Citations

Feb 11, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yoshinaga OkugawaMasato Kusunoki
Jul 10, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K KusunokiM Kusunoki
Mar 31, 2020·Hernia : the Journal of Hernias and Abdominal Wall Surgery·M YildirimI Okan
Jun 21, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Liang-He LuYong-Fa Zhang
Aug 5, 2020·European Journal of Medical Research·Sulmaz GhahramaniFariba Ahmadizar
Mar 8, 2020·Annals of Surgical Oncology·Zhiyao FanXianjun Yu
Jul 10, 2020·International Journal of Molecular Sciences·Alessandro AllegraSebastiano Gangemi

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