Lymphocyte calcium influx characteristics and their modulation by Kv1.3 and IKCa1 channel inhibitors in healthy pregnancy and preeclampsia

American Journal of Reproductive Immunology : AJRI
Gergely ToldiBarna Vásárhelyi

Abstract

Calcium handling of T lymphocytes is altered in healthy pregnancy (HP) and preeclampsia (PE) compared to non-pregnant (non-P) women. We compared the activation-elicited calcium influx in T lymphocytes in HP, PE and non-P women and tested its alteration upon inhibition of Kv1.3 and IKCa1 potassium channels. The alteration of calcium influx was measured in major T-lymphocyte subsets of 9 non-P, HP and PE women with flow cytometry with or without treatment of cells with potassium channel inhibitors. The elicited calcium response was lower in HP compared to non-P. In HP, calcium influx was sensitive to potassium channel inhibition in CD8 and Th1, but not in Th2 cells. In PE, calcium influx and its sensitivity to inhibition were comparable to non-P. There is a characteristic pattern of calcium influx in T lymphocytes and its sensitivity to potassium channel inhibition in HP that is missing in PE, raising the notion that T-lymphocyte calcium handling may have a role in the characteristic immune status of HP.

References

Jan 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A MalinowskiP Wozniak
May 18, 1999·American Journal of Obstetrics and Gynecology·M HojoP August
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·P von DadelszenC W Redman
Oct 6, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D Darmochwal-KolarzJ Oleszczuk
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C M FangerM D Cahalan
Jun 5, 2002·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·M A BrownJ M Moutquin
Feb 28, 2003·American Journal of Reproductive Immunology : AJRI·Dorota Darmochwal-KolarzJan Oleszczuk
Dec 16, 2006·Reproductive Biomedicine Online·Ian L SargentChris W G Redman
Apr 17, 2007·Molecular Aspects of Medicine·Shigeru SaitoYasushi Sasaki
Jun 15, 2007·American Journal of Reproductive Immunology : AJRI·D Darmochwal-KolarzJ Oleszczuk
Jan 1, 2008·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·A S KaposiA Treszl
Jun 3, 2008·Current Opinion in Immunology·Masatsugu Oh-hora, Anjana Rao
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Christopher W G Redman, Ian L Sargent

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Citations

Jan 8, 2013·American Journal of Reproductive Immunology : AJRI·Gergely ToldiAttila Molvarec

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