Lymphocyte Count at 4 Days Postoperatively: A Reliable Screening Marker for Surgical Site Infection After Posterior Lumbar Decompression Surgery

Spine
Eiichiro IwataYasuhito Tanaka

Abstract

Case-control study. To identify laboratory markers for surgical site infection (SSI) in posterior lumbar decompression surgery, which are not affected by operative factors, and to determine the diagnostic cutoffs of these markers. Numerous laboratory markers are used for the early detection of SSI; however, these markers may be affected by operative factors. The study included 182 participants. They were divided into an SSI group (patients who developed deep SSI; n = 8) and a no-SSI group (n = 174). We reviewed data on the C-reactive protein level and total white blood cell count and differential count before posterior lumbar decompression surgery and 1 and 4 days postoperatively. We determined which markers differed significantly between the groups and identified the markers that were not affected by operative factors (operative time, intraoperative blood loss, and number of operative segments) in the no-SSI group. We then determined the diagnostic cutoffs of these unaffected markers using receiver operating characteristic curves. We identified the lymphocyte percentage at 4 days postoperatively (cutoff, <19.4%; sensitivity, 80.0%; specificity, 62.5%; area under the curve, 0.78) and lymphocyte count at 4 days postoperatively (...Continue Reading

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Citations

Oct 30, 2020·Acta neurochirurgica·Markus LenskiSebastian Siller
May 6, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideaki ImabayashiKazuhiro Chiba
May 30, 2021·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hideaki ImabayashiKazuhiro Chiba
Aug 5, 2021·Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders·Hiroaki KijimaYoichi Shimada
Jan 15, 2022·Spinal Cord Series and Cases·Munehisa KoizumiYasuhito Tanaka

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