PMID: 6968241Oct 1, 1980Paper

Lymphocyte cytotoxicity of patients developing multiple primary melanomas

Cancer
B Mukherji, Y Dayal

Abstract

A study of cellular immunity was conducted, with particular attention to natural killer cell mediated in vitro cytotoxicity in 6 patients who had two or three primary melanomas (2 patients presenting synchronously with multiple primaries and additional melanomas subsequently developing in 4). All 6 patients were reactive to one or other recall skin test antigens (PPD, streptokinase streptodornase (SK-SD), monilia, mumps) and DNCB skin testing. All exhibited natural killing against melanoma and nomelanoma tumor target cells when examined in the 3H proline microcytotoxicity test with unfractionated as well as natural killer cell enriched (Fc receptor positive cells recovered as Fc receptor rosettes) lymphocyte fractions. None of the 4 patients who subsequently had additional primary tumors was found to lack in mature T or natural killer cell mediated cytotoxicity at the time of the development of additional primaries. Two melanoma cell lines were established from two separate primary tumors in 1 patient and in vitro cytotoxicity assays were performed with that patient's lymphocytes (unfractionated, T enriched, and natural killer cell enriched fractions) against these two lines. While the first melanoma cell line was consistently ...Continue Reading

References

Mar 1, 1979·Cancer·H S MoseleyD L Morton
Aug 12, 1976·Nature·S A WolfeC S Henney
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Nov 1, 1952·Cancer·G T PACKR A HILLYER

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Citations

Jun 15, 2011·Journal of Bodywork and Movement Therapies·Bhavesh Surendra Mody
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·H F ProssD R MacGillis
Feb 15, 1984·International Journal of Cancer. Journal International Du Cancer·T LindmoA Sundan
Oct 1, 1982·Journal of Clinical Immunology·J C Roder, H F Pross

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