PMID: 6983473Dec 1, 1982Paper

Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg positive chronic liver disease

Gut
G Mieli-VerganiR Williams

Abstract

Lymphocytes from 39 patients with HBsAg positive chronic liver disease were incubated with their own hepatocytes to investigate mechanisms of lymphocyte-mediated liver damage. Cytotoxicity was significantly increased in 46% overall, and in 73% of those with chronic active hepatitis. Unlike HBsAg negative chronic active hepatitis where only non-T cells were cytotoxic, HBsAg positive patients had both cytotoxic T and non-T cells. A purified liver membrane complex (LSP) and aggregated IgG both blocked non-T cytotoxicity without affecting T cell cytotoxicity; this suggests that the former is probably an antibody-dependent cell-mediated reaction against normal membrane components. This was confirmed in preliminary studies which demonstrated that preincubation of hepatocytes with the F(ab)2' fragment of an anti-human IgG reduced non-T lymphocyte cytotoxicity. T-cell cytotoxicity was restricted to HBeAg-positive patients, suggesting a relationship between T-cell cytotoxicity and viral replication. Purified HBsAg, however, blocked cytotoxicity in only three of 11 cases. Non-T lymphocytes reacting with normal membrane components may contribute to liver damage in both 'autoimmune' and virus-associated chronic liver disease, whereas cytot...Continue Reading

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Citations

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J DiaoT I Michalak
Oct 1, 1995·Digestive Diseases and Sciences·A J CzajaS B Moore
Nov 27, 1993·Lancet·J Y Lau, T L Wright
Jul 1, 1987·Baillière's Clinical Gastroenterology·C J O'Brien, A L Eddleston
Feb 1, 1984·Gut·M Mondelli, A L Eddleston
Sep 1, 1991·Gut·A L EddlestonB D Reed
Sep 1, 1991·Gut·J Y LauA Alberti
Sep 1, 1991·Gut·P J Johnson, I G McFarlane
Dec 1, 1994·Journal of Clinical Pathology·M J HussainD Vergani
Aug 1, 1991·Postgraduate Medical Journal·P M HarrisonR Williams
Mar 1, 1994·Postgraduate Medical Journal·S D Ryder, R Williams
Sep 1, 1990·Baillière's Clinical Gastroenterology·J L BrownH C Thomas
Nov 1, 1983·Digestive Diseases and Sciences·A AlbertiG Realdi
Apr 1, 1993·Digestive Diseases and Sciences·R P Perrillo
Oct 1, 1989·Digestive Diseases and Sciences·A AlbertiG Pizzolo
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G RamadoriK H Meyer zum Büschenfelde
Apr 1, 1996·Scandinavian Journal of Clinical and Laboratory Investigation·N OsnaA Sochnev
Jan 10, 2016·Journal of Autoimmunity·Rodrigo LiberalM Eric Gershwin
Apr 1, 1986·Cellular Immunology·C M Chu, Y F Liaw
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N V NaumovR Williams
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C M ChuY F Liaw
Sep 1, 1988·European Journal of Immunology·S C MeuerK H Meyer zum Büschenfelde
Aug 1, 1988·Journal of Hepatology·C FerrariF Fiaccadori
Jan 1, 1986·Journal of Hepatology·A L Eddleston, M Mondelli
Jan 1, 1989·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Y Y Zhang, L J Hao
Jul 1, 1986·Gut·E A Fagan, R Williams
Feb 1, 1986·Australian and New Zealand Journal of Medicine·M MackinnonR A Smallwood
May 26, 1984·British Medical Journal·P PontissoC Brechot

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