Lymphocyte density determined by computational pathology validated as a predictor of response to neoadjuvant chemotherapy in breast cancer: secondary analysis of the ARTemis trial.

Annals of Oncology : Official Journal of the European Society for Medical Oncology
H R AliCarlos Caldas

Abstract

We have previously shown lymphocyte density, measured using computational pathology, is associated with pathological complete response (pCR) in breast cancer. The clinical validity of this finding in independent studies, among patients receiving different chemotherapy, is unknown. The ARTemis trial randomly assigned 800 women with early stage breast cancer between May 2009 and January 2013 to three cycles of docetaxel, followed by three cycles of fluorouracil, epirubicin and cyclophosphamide once every 21 days with or without four cycles of bevacizumab. The primary endpoint was pCR (absence of invasive cancer in the breast and lymph nodes). We quantified lymphocyte density within haematoxylin and eosin (H&E) whole slide images using our previously described computational pathology approach: for every detected lymphocyte the average distance to the nearest 50 lymphocytes was calculated and the density derived from this statistic. We analyzed both pre-treatment biopsies and post-treatment surgical samples of the tumour bed. Of the 781 patients originally included in the primary endpoint analysis of the trial, 609 (78%) were included for baseline lymphocyte density analyses and a subset of 383 (49% of 781) for analyses of change i...Continue Reading

References

Jun 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H R AliC Caldas
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sylvia AdamsSunil S Badve
Jul 21, 2015·Nature Medicine·Andrew J GentlesAsh A Alizadeh
May 31, 2016·Breast Care·Barbara Ingold HeppnerCarsten Denkert
Oct 16, 2016·Journal of the National Cancer Institute·Rico D BenseRudolf S N Fehrmann
May 27, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jeremy St John ThomasHelena Margaret Earl

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Citations

Sep 14, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne-Sophie HamyFabien Reyal
Jun 18, 2021·Frontiers in Immunology·Jonathan GoldbergJennifer L Guerriero
Mar 19, 2021·Applied Immunohistochemistry & Molecular Morphology : AIMM·Haydee LaraLiron Pantanowitz
Jan 26, 2021·Archives of Pathology & Laboratory Medicine·James H HarrisonMichelle N Stram

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