Lymphocyte-derived interferon-gamma mediates ischemia-reperfusion-induced leukocyte and platelet adhesion in intestinal microcirculation.

American Journal of Physiology. Gastrointestinal and Liver Physiology
Mohammad OsmanD Neil Granger

Abstract

Although previous studies have implicated lymphocytes in the gut microvascular and inflammatory responses to ischemia-reperfusion (I/R), the lymphocyte population and lymphocyte-derived products that mediate these responses have not been defined. Platelet and leukocyte adhesion was measured in intestinal postcapillary venules of wild-type (WT) mice and mice genetically deficient in either CD4+ T cells (CD4-/-), CD8+ T cells (CD8-/-), B cells (B cell-/-), or interferon-gamma (IFN-gamma-/-) subjected to 45 min of ischemia and 4 h of reperfusion. The I/R-induced platelet and leukocyte recruitment responses were also evaluated following adoptive transfer of WT splenocytes into CD4-/-, CD8-/-, B cell-/-, and IFN-gamma-/- mice. WT mice exposed to gut I/R exhibited significant increases in the adhesion of both platelets and leukocytes, compared with sham-WT mice. These blood cell adhesion responses to I/R were greatly attenuated in CD4-/-, CD8-/-, B cell-/-, and IFN-gamma-/- mice. Adoptive transfer of WT splenocytes restored the WT responses to I/R in all mutants except the B cell-/- mice. These findings implicate both T and B cells and lymphocyte-derived IFN-gamma as mediators of the proinflammatory and prothrombogenic phenotype assu...Continue Reading

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Citations

Mar 20, 2010·Cardiovascular Research·Stephen F Rodrigues, D Neil Granger
Aug 27, 2010·American Journal of Physiology. Renal Physiology·David L Mattson
Sep 14, 2011·Hypertension·Elena Y SenchenkovaD Neil Granger
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Yan-Fang GuanMarshall H Montrose
May 10, 2011·Internal and Emergency Medicine·Antonio Di SabatinoGino R Corazza
Dec 14, 2011·Free Radical Biology & Medicine·Peter R Kvietys, D Neil Granger
Dec 17, 2010·World Journal of Cardiology·Mozow Y Zuidema, Cuihua Zhang
Dec 31, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S SuzukiT Hibi
Sep 10, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazuhisa YoshiyaGeorge C Tsokos

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