PMID: 490180Aug 1, 1979Paper

Lymphocyte function in myasthenia gravis

Journal of Neurology, Neurosurgery, and Psychiatry
S KawanamiY Kuroiwa

Abstract

Mitogen-induced blastoid transformation of peripheral blood lymphocytes from patients with myasthenia gravis was studied using a microplate culture technique and evaluated with 3H-thymidine incorporation. It was found that both phytohaemagglutinin and pokeweed mitogen responses decreased significantly in patients with myasthenia gravis. In myasthenic crisis, indices of stimulation by phytohaemagglutination became very low. The autologous plasma neither inhibited nor facilitated mitogenic responses of lymphocytes. The decreased mitogen responsiveness of lymphocytes suggests that part of the T lymphocyte function is subnormal in myasthenia.

References

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Citations

Oct 1, 1981·Journal of the Neurological Sciences·H C ChiuT P Hung
Nov 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·H J SagarI D Allonby
Jul 1, 1980·Journal of Neurology, Neurosurgery, and Psychiatry·P O Behan
Jan 1, 1985·Springer Seminars in Immunopathology·A I LevinsonM Kornstein
Jan 1, 1981·Annals of the New York Academy of Sciences·S M KoetheM P McQuillen

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