PMID: 6989877May 1, 1980Paper

Lymphocyte function in relapsed pulmonary blastomycosis

The Journal of Allergy and Clinical Immunology
P G SohnleH D Rose

Abstract

Lymphocyte function was studied in two patients with multiple relapses of pulmonary blastomycosis following antifungal therapy. Neither patient was anergic to routine delayed hypersensitivity skin testing with common antigens. Both had normal in vitro lymphocyte transformation responses to standard mitogens and common microbial antigens. The ability of lymphocytes from the two patients to respond to antigens of the infecting organism was evaluated using a yeast phase Blastomyces dermatitidis extract in tests of in vitro lymphocyte function. Both patients demonstrated positive responses to this extract in standard assays of two in vitro parameters of lymphocyte function, lymphocyte transformation, and lymphokine production. Therefore if an immunologic defect is responsible for the repeated relapses of treated pulmonary blastomycosis in these two patients, it apparently is not one of deficient lymphocyte responsiveness against the infecting organism, as has been found using similar techniques in patients with disseminated deep infections caused by other fungal organisms.

References

Jul 1, 1978·The Journal of Clinical Investigation·P G Sohnle, C Collins-Lech
Feb 1, 1976·The Journal of Clinical Investigation·J D StoboP E Hermans
Feb 1, 1975·Cellular Immunology·A CatanzaroK M Moser
Jan 1, 1974·International Archives of Allergy and Applied Immunology·B A WaltersW J Halliday
Apr 1, 1974·Cellular Immunology·D A StevensT F Waddell
May 1, 1973·Transactions of the New York Academy of Sciences·M L Furcolow, C D Smith
Mar 1, 1974·Annals of Internal Medicine·C H Kirkpatrick, T K Smith
Jun 1, 1971·Annals of Internal Medicine·C H KirkpatrickJ E Bennett

❮ Previous
Next ❯

Citations

Jun 30, 1984·Mycopathologia·R Miller-Catchpole, J W Rippon
Jan 1, 1988·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·C J CzuprynskiR D Schultz
Sep 29, 2012·Pediatric Dermatology·Katherine E BrickSheila S Galbraith
Feb 24, 2006·Emerging Infectious Diseases·Shaun K MorrisE Lee Ford-Jones
Jan 1, 1985·Scandinavian Journal of Thoracic and Cardiovascular Surgery·P K GoshB A Vidne
Feb 1, 1983·Australian and New Zealand Journal of Medicine·S R HoldsworthJ P Dowling

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.