PMID: 6977367Jan 1, 1982Paper

Lymphocyte function in untreated Hodgkin's disease: an important predictor of prognosis

British Journal of Cancer
C WedelinH Mellstedt

Abstract

One hundred and twenty seven consecutive and previously untreated patients with Hodgkin's disease (HD) (mean age 47 years) from the Stockholm area admitted to Radiumhemmet, Karolinska Hospital, were studied. The age-matched control group consisted of 167 healthy adults. Incorporation of [14C]-dT was measured on Day 1 in unstimulated monocyte-depleted lymphocyte cultures, and on Day 3 in cultures activated by PWM, ConA and PPD, T and B cells were enumerated by surface markers. The patients had significantly decreased relative and total T-cell counts, and the lymphocyte DNA synthesis induced by mitogens and PPD was severely impaired, whilst the spontaneous DNA synthesis was significantly greater than in controls. At follow-up (mean 4 years) 40 patients have died. Deceased patients showed greater spontaneous lymphocyte activation and less response to mitogen and antigen stimulation than the survivors. The 5-year survival of patients with severe lymphocyte impairment was 20%, compared to 80% for the remainder. The lymphocyte tests added prognostic information to that from clinical staging. Disregarding the lack of knowledge of the mechanisms underlying the lymphocyte impairment, we suggest that these relatively simple immunological...Continue Reading

Citations

Jan 21, 1992·International Journal of Cancer. Journal International Du Cancer·R N DamleS G Gangal
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·F GriesingerP S Mitrou
Jan 1, 1982·Scandinavian Journal of Haematology·C WedelinH Mellstedt
Sep 15, 1984·Cancer·M BjörkholmB Essy-Ehsing
Mar 1, 1985·Acta Radiologica. Oncology·B ErikssonC Källander
Jan 15, 2011·Breast Cancer : Basic and Clinical Research·Ourania KostiYun-Ling Zheng
Jan 1, 1984·Medical Oncology and Tumor Pharmacotherapy·C WedelinH Mellstedt

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