Lymphocyte immunotherapy for recurrent miscarriages: Predictors of therapeutic success

American Journal of Reproductive Immunology : AJRI
Marcelo Borges CavalcanteJorge Neumann

Abstract

To evaluate the predictors of successful pregnancies in women with a history of recurrent miscarriages (RMs) having undergone lymphocyte immunotherapy (LIT). Retrospective, multicenter, observational study which involved 702 pregnant women with history of RM treated with LIT. Comparative analysis of women with a history of RM having undergone LIT and experienced treatment success vs those having experienced treatment failure along with the analysis of the association between the number of prior miscarriages and the efficacy of LIT. A total of 421 women were able to carry the pregnancy to term, with treatment success rate of 60%. The multivariate analysis showed that age, the association between autoantibodies and thrombophilia, and the number of previous miscarriages were factors associated with LIT failure. Secondary RMs alone were not found to be a factor predictive of LIT success or failure; however, secondary RMs among women with a history of 5 or more RM were found to be a predictor of LIT success (OR: 10.24; 95% CI: 1.9-55.8; P = .007). Age, the number of previous miscarriages, and the association between autoantibodies and thrombophilia are associated with LIT failure. A higher number of previous miscarriages in cases of...Continue Reading

References

Mar 21, 1991·European Journal of Obstetrics, Gynecology, and Reproductive Biology·U B KnudsenN J Secher
Aug 27, 1966·Nature·B Clarke, D R Kirby
Jul 11, 1981·Lancet·C Taylor, W P Faulk
Mar 1, 1993·American Journal of Reproductive Immunology : AJRI·P A GatenbyT J Doran
Apr 1, 1996·American Journal of Reproductive Immunology : AJRI·C B CoulamD A Clark
Dec 28, 2000·American Journal of Reproductive Immunology : AJRI·H MatsubayashiT Makino
Dec 4, 2003·Archives of Gynecology and Obstetrics·Manoj Kumar PandeySuraksha Agrawal
Apr 12, 2005·Fertility and Sterility·Ole B ChristiansenKatrin van der Ven
Apr 4, 2006·American Journal of Obstetrics and Gynecology·Berthold HuppertzJohn C P Kingdom
Nov 7, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Marcos Roberto CaetanoRicardo Barini
Oct 26, 2012·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
May 10, 2013·American Journal of Reproductive Immunology : AJRI·Zofia Maria PiosikOle Bjarne Christiansen
Feb 20, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·S Feodor NilssonA-M Nybo Andersen
Jul 10, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marcelo Borges CavalcanteRicardo Barini
Oct 30, 2015·American Journal of Reproductive Immunology : AJRI·Sung Ki LeeJoanne Kwak-Kim
Mar 24, 2016·Human Fertility : Journal of the British Fertility Society·Mona FawzyMostafa Metwally
Sep 27, 2016·Obstetrics & Gynecology Science·Gi Su LeeJong In Kim
Dec 23, 2016·Archives of Gynecology and Obstetrics·Marcelo Borges CavalcanteRicardo Barini
May 30, 2017·International Journal of Women's Health·Hady El HachemPierre-Emmanuel Bouet
Aug 2, 2017·Fertility and Sterility·Fernando Zegers-HochschildSheryl van der Poel

❮ Previous
Next ❯

Citations

Jul 22, 2020·Emerging Topics in Life Sciences·David A Clark
Dec 11, 2019·American Journal of Reproductive Immunology : AJRI·Marcelo Borges CavalcanteRicardo Barini
Oct 15, 2020·Archives of Gynecology and Obstetrics·Marcelo Borges CavalcanteRicardo Barini
Feb 28, 2021·American Journal of Reproductive Immunology : AJRI·Marcelo Borges CavalcanteRicardo Barini
Jul 19, 2020·International Immunopharmacology·Roghayeh JafarpourMorteza Motallebnezhad
Jun 9, 2021·Immunity, Inflammation and Disease·Sudong LiuRuiqiang Weng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Marcelo Borges CavalcanteRicardo Barini
© 2022 Meta ULC. All rights reserved