Lymphocyte lineages at mucosal effector sites: rat salivary glands

The Journal of Immunology : Official Journal of the American Association of Immunologists
N L O'SullivanP C Montgomery

Abstract

Development of T cell lineages and the role of the thymus as a source of immature T cells in parotid (PG) and submandibular salivary glands (SMG) were studied in Fischer 344 rats using the Thy-1/CD45RC/RT6 expression model. In addition, the phenotypes of salivary gland lymphocytes were compared with other conventional and extrathymic populations. PG mononuclear cells consisted of T cells (38%), B cells (29%), and NK cells (4%). SMG had 19% T cells, 7% B cells, 37% NK cells, and an unusual population of CD3(-)/RT6(+) cells. In comparison with lymph node (LN), both PG and SMG were enriched in immature (Thy-1(+)) and activated (Thy-1(-)/CD45RC(-)/RT6(-)) T cells. Unchanged percentages of Thy-1(+) T cells in PG and SMG following short-term adult thymectomy indicated that immature salivary gland T cells had an extrathymic source. In contrast, thymectomy eliminated LN recent thymic emigrants. SMG had T cells with characteristics of extrathymic populations, expressing TCRgammadelta(+) (28%), the CD8alphaalpha homodimer (11%), and NKR-P1A (66%). Many SMG T cells expressed integrin alpha(E)beta(7). PG T cells resembled those isolated from LN in respect to TCR and CD8 isoform usage, but were enriched in alpha(E)beta(7)(+) T cells and in ...Continue Reading

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Citations

Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Maike Hofmann, Hanspeter Pircher
Jan 21, 2011·PLoS Pathogens·Marlowe S TessmerLaurent Brossay
Mar 16, 2016·The British Journal of Nutrition·Malen Massot-CladeraMargarida Castell
Feb 23, 2007·Journal of Dental Research·F X Lü, R S Jacobson
Mar 22, 2008·The Journal of Clinical Investigation·Nora MüllerHolger M Reichardt
Oct 16, 2001·Current Eye Research·N L O'SullivanP C Montgomery
Feb 27, 2007·The American Journal of Pathology·Jens van den BrandtHolger M Reichardt

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