PMID: 58460Jan 1, 1976Paper

Lymphocyte-mediated cytotoxicity against tumor cells specificity and characterization of concanavalin A-activated cytotoxic effector lymphocytes

Transplantation Reviews
J D WaterfieldG Möller

Abstract

The selective T cell mitogen Con A was found to induce cytotoxic effectorlymphocytes after in vivo or in vitro treatment. The effector cells exhibited immunologic specificity when tested against tumor cells, killing targets only across H-2 histocompatibility barriers. Thus, Con A caused a polyclonal T cell activation, resulting in the appearance of effector cells capable of recognizing all H-2 antigens, except those coded for by the major histocompatibility loci of the lymphocyte donor. These experiments demonstrate that Con A is capable of activating pre-existing T cells to reveal their genetically determined immunological specificity, and furthermore suggest that there is a deletion of T cell clones with specificity for self. The activated effector cells were characterized as T blasts being relatively insensitive to treatment with anti-O serum plus complement. The precursors of the Con A-activated effector cells were shown to reside primarily in the spleen, to be radio-resistant up to 400 R, and to be short-lived after adult thymectomy. Thus, the population of T cells capable of activation to cytotoxic effector lymphocytes by Con A has similar physical characteristics to the splenic subset(s) of T cells mediating both GVH and...Continue Reading

References

Jun 1, 1975·Cellular Immunology·W R Clark
Sep 1, 1973·The Journal of Experimental Medicine·J Forman, G Möller
Feb 1, 1973·The Journal of Experimental Medicine·J Forman, S Britton
Jul 1, 1972·Transplantation·G NirmulR N Taub
Aug 1, 1972·European Journal of Immunology·J AnderssonG Möller
Mar 1, 1973·Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme·K Nomoto
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jan 31, 1969·Science·H MarkowitzR E Ritts
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Jul 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M A Leon, H J Schwartz
Aug 26, 1966·Science·R I Mishell, R W Dutton

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Citations

May 1, 1977·The Journal of Experimental Medicine·L M PilarskiL L Baum
Jan 1, 1977·Immunological Reviews·T WatanabeA Coutinho

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