PMID: 6985378Jun 1, 1982Paper

Lymphocyte studies in a patient with neurological complications of Behçet's syndrome

Clinical Rheumatology
R MallyaH Berry

Abstract

We rapport here a case of Behcet's disease presenting with neurological complications who made a remarkable recovery to high dose steroids and azathioprine. Prior to initiation of steroid therapy the percentage of T lymphocytes (OKT3) was low, that of helper T lymphocytes (OKT4) was normal and suppressor T lymphocytes (OKT8) was slightly increased. The OKT4: OKT8 ratio was slightly reduced and the percentage of B lymphocytes was high. With steroid therapy there was an increase in the percentage of OKT3 and fall in the percentages of OKT4 and OKT8 and the OKT4: OKT8 ratio was maintained fairly normal. The percentage of B lymphocytes was reduced. On addition of azathioprine the percentage of OKT3 and OKT8 were substantially increased and the percentage of OKT4 was slightly increased. The net result was a significant reduction in the OKT4: OKT8 ratio. The percentage of B lymphocytes remained normal. On reviewing the absolute counts there was a paradoxical rise in OKT4 and OKT8 a week after high dose steroid therapy due to a substantial rise in the total number of lymphocytes. On reducing the dose of steroids the absolute count of OKT4 and OKT8 decreased in parallel with their percentages. A disparity was noted in the percentage of...Continue Reading

References

Jan 1, 1976·Dermatologica·S HaimE Robinson
Mar 1, 1965·Archives of Neurology·S M WOLFL L PHILLIPS

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Citations

Feb 1, 1995·Alcoholism, Clinical and Experimental Research·S BarronE P Riley
Jun 1, 1987·Alcoholism, Clinical and Experimental Research·S J KellyJ R West
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Dec 18, 2018·The Cochrane Database of Systematic Reviews·Aleena M WojcieszekVicki Flenady

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