Abstract
In this study, we evaluated lymphocyte subpopulations in 23 adults with SCA. When compared to controls, SCA patients had higher lymphocyte counts with normal numbers of T101+ cells (T-lymphocytes) and T4+ cells. T8+ cells were significantly increased in SCA patients in comparison to controls (1684 +/- 243 vs 980 +/- 367, p less than .001). This increment was largely dependent on a T101-, T8+ cell population. The SCA patients as a group had significantly decreased T4/T8 ratio (p less than .0001). The SCA patients with history of blood transfusions had higher T4+ cells numbers and higher T4/T8 ratio, but no other significant differences from nontransfused patients were noted. Our results are different from those reported for nontransfused children with SCA who showed normal T4/T8 ratio. Thus, a distinct pattern of abnormalities is seen in the lymphocyte subpopulations of adult SCA patients, unrelated to their exposure to blood transfusions.
References
Mar 1, 1971·Medicine·E Barrett-Connor
Apr 30, 1983·Lancet·A J AmmannH A Perkins
Feb 1, 1984·Annals of Internal Medicine·P GascónN S Young
Aug 1, 1983·Annals of Internal Medicine·M S GottliebR Detels
Feb 1, 1983·Annals of Internal Medicine·O F Ballester, A S Prasad
Nov 1, 1980·Clinical Immunology and Immunopathology·E W AdesS K Morgan
Nov 1, 1983·Annals of Internal Medicine·J R JettH A Homburger
Jun 1, 1983·Annals of Internal Medicine·K R RaoJ R Pattison
Citations
Sep 1, 1995·International Journal of Immunopharmacology·E MocchegianiN Fabris
Apr 1, 1996·The Pediatric Infectious Disease Journal·S C TaylorR A Mitchell
Oct 1, 1988·The Journal of Clinical Investigation·A S PrasadM Dardenne
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Bianca Maria RicercaDeborah Rund
Aug 5, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Bin BaoPaul Swerdlow
May 31, 2013·American Journal of Hematology·Weili BaoKarina Yazdanbakhsh
Aug 1, 1997·The Journal of Laboratory and Clinical Medicine·F W BeckA S Prasad
Jun 9, 2019·Antioxidants·Ananda S Prasad, Bin Bao
Jul 9, 1999·American Journal of Hematology·A S PrasadP Swerdlow
Apr 1, 1987·American Journal of Hematology·J D ReedE P Orringer
Dec 1, 1991·Immunological Investigations·S TaylorG Dinkins
Aug 1, 1988·American Journal of Hematology·J M AbdallahA S Prasad
May 10, 2000·The Journal of Nutrition·M K BaumA Campa
Nov 1, 1987·American Journal of Hematology·O CastroW Frederick