PMID: 3754689Jan 1, 1986Paper

Lymphocyte subpopulation abnormalities in sickle cell anemia: a distinctive pattern from that of AIDS

American Journal of Hematology
O F BallesterA S Prasad

Abstract

In this study, we evaluated lymphocyte subpopulations in 23 adults with SCA. When compared to controls, SCA patients had higher lymphocyte counts with normal numbers of T101+ cells (T-lymphocytes) and T4+ cells. T8+ cells were significantly increased in SCA patients in comparison to controls (1684 +/- 243 vs 980 +/- 367, p less than .001). This increment was largely dependent on a T101-, T8+ cell population. The SCA patients as a group had significantly decreased T4/T8 ratio (p less than .0001). The SCA patients with history of blood transfusions had higher T4+ cells numbers and higher T4/T8 ratio, but no other significant differences from nontransfused patients were noted. Our results are different from those reported for nontransfused children with SCA who showed normal T4/T8 ratio. Thus, a distinct pattern of abnormalities is seen in the lymphocyte subpopulations of adult SCA patients, unrelated to their exposure to blood transfusions.

References

Feb 1, 1984·Annals of Internal Medicine·P GascónN S Young
Aug 1, 1983·Annals of Internal Medicine·M S GottliebR Detels
Nov 1, 1980·Clinical Immunology and Immunopathology·E W AdesS K Morgan
Nov 1, 1983·Annals of Internal Medicine·J R JettH A Homburger
Jun 1, 1983·Annals of Internal Medicine·K R RaoJ R Pattison

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Citations

Oct 1, 1988·The Journal of Clinical Investigation·A S PrasadM Dardenne
Jan 1, 2009·Mediterranean Journal of Hematology and Infectious Diseases·Bianca Maria RicercaDeborah Rund
Aug 5, 2008·Translational Research : the Journal of Laboratory and Clinical Medicine·Bin BaoPaul Swerdlow
Apr 1, 1987·American Journal of Hematology·J D ReedE P Orringer
Dec 1, 1991·Immunological Investigations·S TaylorG Dinkins
Aug 1, 1988·American Journal of Hematology·J M AbdallahA S Prasad
May 10, 2000·The Journal of Nutrition·M K BaumA Campa
Nov 1, 1987·American Journal of Hematology·O CastroW Frederick

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