PMID: 6979523Jan 1, 1982Paper

Lymphocyte subpopulations and lymphocyte function in phenytoin-treated patients with epilepsy

International Journal of Immunopharmacology
N E GilhusJ A Aarli

Abstract

The number of leukocytes and the percentage of cells in various mononuclear subpopulations were determined in 22 patients with epilepsy. The lymphocyte response to PHA were examined in the patients and in selected controls. The patients were grouped according to phenytoin treatment at present or previously, and according to the presence or absence of serum IgA depression. Patients taking phenytoin demonstrated reduced leukocyte counts. The lowest counts were found in phenytoin-treated patients with markedly reduced IgA concentrations. The number of lymphocytes were reduced more than the total leukocyte count in the patients. No significant differences were observed between patients and controls regarding percentage of cells with membrane-bound immunoglobulins, active E-rosetting cells, AET-rosetting cells, EA-rosetting cells, EAC-rosetting cells, and cells with a capacity of phagocytosis. The mean response to PHA stimulation (PHA concentration 0.6 micrograms/ml) was 4634 counts per minute in the patients and 6132 counts per minute in the controls. However, the response to this stimulation varied considerably between individuals in both groups, and the difference between the 2 groups was not statistically significant.

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Citations

Jan 1, 1981·Journal of Neurology·N E Gilhus, J A Aarli
Mar 1, 1989·Journal of Neurology·N E Gilhus, T Lea
Jan 1, 1983·European Journal of Clinical Pharmacology·O MeissnerW Studzinski
Jan 1, 1982·International Journal of Immunopharmacology·N E GilhusJ A Aarli
Jan 1, 1983·International Journal of Immunopharmacology·N E Gilhus
Oct 1, 1992·International Journal of Immunopharmacology·M L Queiroz, P W Mullen
May 1, 1995·International Journal of Immunopharmacology·S M Furst, J P Uetrecht
Mar 1, 1992·Schizophrenia Research·W W EatonR Ram
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Jan 1, 1987·Epilepsia·N C Margaretten, R P Warren
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Nov 1, 1988·Acta Neurologica Scandinavica·O Eeg-OlofssonN A Janjua
Jun 1, 1986·Scandinavian Journal of Dental Research·G DahllöfT Modéer
Dec 1, 1985·Scandinavian Journal of Dental Research·G DahllöfK G Sundqvist
Sep 1, 1986·Acta Neurologica Scandinavica·N E Gilhus, R Matre
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