PMID: 2484652Jan 1, 1988Paper

Lymphocyte subpopulations and lymphokine production in children with constitutional aplastic anemia

Pediatric Hematology and Oncology
M DohlstenR Carlsson

Abstract

The expression of lymphocyte surface markers as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN) by mitogen-stimulated peripheral blood mononuclear cells (MNC) have been studied in five children with constitutional aplastic anemia. A significantly reduced T4/T8 ratio was found and two of five patients also had a reduced percentage of B cells. One patient had a high percentage of HLA-DR positive T8+ cells, very suggestive of a high degree of circulating activated T suppressor/cytotoxic cells. IL-2 production was reduced in two patients, whereas IFN production was only reduced in one of these. The abnormalities found correlate with the duration of the bone marrow failure. The patients with the longest duration of bone marrow failure also exhibited the lowest T4/T8 ratio. No spontaneous IFN production was detected in any of the patients. There was no clinical benefit or reversal of the immune abnormalities during and following treatment with cimetidine and cyclosporine A in two patients.

References

Mar 1, 1979·The American Journal of Medicine·W A KaganR A Good
Jan 31, 1985·The New England Journal of Medicine·N C ZoumbosN S Young
Jan 1, 1986·Pediatric Hematology and Oncology·M DohlstenS Garwicz
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·N C ZoumbosN S Young
Jan 20, 1983·The New England Journal of Medicine·A J WatsonE Bourke
Sep 1, 1984·British Journal of Haematology·N C ZoumbosN Young
Jan 1, 1984·The American Journal of Pediatric Hematology/oncology·J S Lilleyman
Mar 8, 1984·The New England Journal of Medicine·P A StryckmansL Debusscher

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.