PMID: 6974088Oct 1, 1981Paper

Lymphocyte subpopulations in bronchoalveolar lavages of patients with sarcoidosis and hypersensitivity pneumonitis

Chest
P GodardF B Michel

Abstract

Sarcoidosis and hypersensitivity pneumonitis (HP) are two granulomatous pulmonary diseases, the former of unknown cause and the latter with known etiology. To compare these diseases, we practiced bronchoalveolar lavage on 16 patients with sarcoidosis, 6 with HP, 10 healthy nonsmokers, and 10 smokers with chronic bronchitis. Lymphocyte subpopulations were evaluated by four membrane markers: (1) The total cell count was very high in patients with HP compared with those with sarcoidosis and with healthy subjects. (2) The proportion of lymphocytes was higher in patients with HP than in those with sarcoidosis (P less than 0.02) and also higher in patients with sarcoidosis than in healthy subjects (P less than 0.001). (3) There were only a small number of B cells and of Fc-receptor bearing cells. (4) The lymphocytes identified by our techniques were mainly T cells in sarcoidosis and HP (68.4 +/- 3.5 percent and 76.8 +/- 3.6 percent, respectively), but the proportion of "active" E-rosette-forming cells was higher in sarcoidosis than in HP (28.1 +/- 2.5 percent vs 9.8 +/- 1.5 percent) and higher in patients with HP than in healthy subjects. These studies suggest that: (1) these two granulomatoses may be differentiated by this method, w...Continue Reading

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Citations

Nov 6, 1986·Journal of Immunological Methods·P JolyP Saliou
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine
Jul 5, 2006·Orphanet Journal of Rare Diseases·Yves Lacasse, Yvon Cormier
Sep 1, 1983·American Journal of Ophthalmology·J ChessB Kaynor
Jan 23, 2010·Current Opinion in Allergy and Clinical Immunology·Mélissa Girard, Yvon Cormier
Jul 1, 1984·Journal of the American Academy of Dermatology·F A Kerdel, S L Moschella
Feb 13, 2009·Allergy·M GirardY Cormier
Feb 1, 1987·Seminars in Arthritis and Rheumatism·R B EvansS R Kaplan
Dec 1, 1983·Journal of Cutaneous Pathology·E M McMillan
Jun 1, 1988·Journal of Cutaneous Pathology·Y KuramotoH Tagami
Aug 1, 1982·The Journal of Allergy and Clinical Immunology·P GodardF B Michel
Aug 1, 1993·Chest·R H WinterbauerS C Springmeyer
May 1, 1987·Chest·W B Davis, J E Gadek
Mar 1, 2012·Clinics in Chest Medicine·Ulrich CostabelJosune Guzman
Apr 18, 2017·American Journal of Respiratory and Critical Care Medicine·Christopher J RyersonHarold R Collard
Jan 1, 1986·Annals of the New York Academy of Sciences·G CordierJ P Revillard
Jul 25, 2020·American Journal of Respiratory and Critical Care Medicine·Ganesh RaghuKevin C Wilson

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