PMID: 6971039Sep 1, 1980Paper

Lymphocyte subpopulations in cerebrospinal fluid and peripheral blood in multiple sclerosis

Acta Neurologica Scandinavica
P E ManconiD Zaccheo

Abstract

Lymphocytes subpopulations in cerebro-spinal fluid (CSF) and peripheral blood (PB) from multiple sclerosis (MS) patients were studied. PB of MS patients contains the same prevalence of E and EA rosette forming cells compared with controls, consisting of patients affected by various "nonimmunological" neuropsychiatric diseases. Cytochemical identification by the method of acid esterases in PB demonstrated in MS a prevalence of lymphocyte subpopulations similar to controls, and a relatively high percentage of macrophages compared with other methods, especially in MS patients: this may partially account for variable results obtained by various authors with the rosette technique. In CSF a significant decrease of total T, and particularly of T gamma cells, was found. Since T gamma lymphocytes have a suppressor effect on B cell proliferation and Ig synthesis, their decrease could be related with Ig hypersynthesis commonly found in the central nervous system of MS patients.

References

Jun 1, 1976·Neurology·A S RoseW W Tourtellotte
Nov 1, 1978·Acta Neurologica Scandinavica·H Nyland, A Naess
Sep 1, 1979·Journal of the Neurological Sciences·H J Sagar, I D Allonby
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Jan 1, 1976·The New England Journal of Medicine·A Rivenson, R E Madden
May 1, 1975·Neurology·J F OgerJ P Kistler

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Citations

Sep 1, 1988·Acta Neurologica Scandinavica·J De Reuck, P Vanderdonckt
Mar 1, 1985·Acta Neurologica Scandinavica·M ZaffaroniC L Cazzullo
Feb 1, 1986·Italian Journal of Neurological Sciences·M G MarrosuM G Ennas
Jun 1, 1983·Arquivos de neuro-psiquiatria·L R Machado

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