PMID: 6966117Mar 1, 1980Paper

Lymphocyte subpopulations in patients with various immunodeficiencies

Acta paediatrica Scandinavica
F Gmelig-MeylingJ W Stoop

Abstract

We have studied patients with various immunodeficiencies for the occurrence of blood lymphocytes bearing six different surface markers: the affinity to sheep erythrocytes (Es) to identify T cells, the presence of surface-bound immunoglobulins (sIg) to distinguish B cells, the affinity to mouse erythrocytes (Em) as a second B cell marker, and the receptors for the Fc part of IgM (IgM-FcR), the Fc part of IgG (IgG-FcR) and for complement (CR). IgG-FcR bearing lymphocytes were present in normal proportions and the same was found for CR-positive lymphocytes. None of the patients with congenital agammaglobulinaemia had sIg-bearing or Em-binding B lymphocytes. Four patients with ataxia teleangiectasia had low B cells and 3 out of 4 also had low proportions of IgM-FcR-bearing (T) cells. A child with partial DiGeorge syndrome did not have a grossly abnormal marker pattern although there appeared to be a shift in the T/B cell ratio in favour of the B cells. In a patient with selective cellular immunodeficiency associated with a purine nucleoside phosphorylase deficiency, who was followed during reconstitution therapy with plasma and red cells, a positive change in the marker pattern was seen. Similar observations were made in a child wi...Continue Reading

References

Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R J WinchesterH E Broxmeyer
Oct 1, 1977·European Journal of Immunology·L MorettaM D Cooper
Mar 24, 1977·The New England Journal of Medicine·J W StoopR E Ballieux
Dec 9, 1976·The New England Journal of Medicine·S H PolmarR Hirschhorn
Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S GuptaF P Siegal
Jan 1, 1976·Scandinavian Journal of Immunology·F Gmelig-MeylingR E Ballieux
Sep 1, 1975·Scandinavian Journal of Immunology·A R Hayward, M F Greaves
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Jan 1, 1980·Acta paediatrica Scandinavica·F Gmelig-MeylingR E Ballieux

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