Lymphocyte subset pattern in acromegaly

Journal of Endocrinological Investigation
A ColaoG Lombardi

Abstract

Immune function in acromegalic patients has been poorly investigated. The aim of this study was to evaluate the main surface antigen clusters of circulating lymphocytes in acromegaly. One hundred patients with active acromegaly (55 women and 45 men, aged 20-70 yr) and 200 healthy subjects sex- and age-matched with the patients (110 women and 90 men, aged 20-70 yr) were enrolled in this study. All patients and controls were born and live in Southern Italy. No patient had received octreotide, bromocriptine or corticosteroids for at least 3 months before entering the study. The analysis of lymphocyte subset pattern was performed by flow cytometry and fluorescein isothiocyanate or phycoerythrin directly conjugated monoclonal antibodies specific for the cell surface antigen clusters (CD) representing T-cell population as a whole (CD3), T helpers (CD4), T suppressors (CD8), natural killer cells (CD16) and B-cell population as a whole (CD19). Acromegalics had significantly increased levels of CD3 (67.1+/-7.2 vs 64.3+/-8.8%; p=0.03) and CD4 (37.8+/-3.5 vs 36.4+/-4.3%; p=0.004) and decreased levels of CD8 (31.4+/-3.3 vs 33.7+/-8.2%; p<0.01) and CD19 (12.1+/-3.1 vs 15.2+/-5.1; p=0.01) without age-difference. The results of the current st...Continue Reading

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Citations

Sep 27, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Janet L Crane, Xu Cao
Feb 15, 2008·Heart and Vessels·Pietro MaffeiNicola Sicolo
Feb 25, 2009·Clinical and Experimental Immunology·A MukherjeeS M Shalet
Feb 25, 2009·Annals of the New York Academy of Sciences·Mireille DardenneWilson Savino
Jul 25, 2012·Annals of the New York Academy of Sciences·Wilson SavinoMireille Dardenne
Dec 31, 2009·Clinical Endocrinology·Annice MukherjeeStephen Shalet
Dec 18, 2013·Aging Cell·Zhenwei GongShoshana Yakar
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Mar 11, 2005·European Journal of Endocrinology·Thor Ueland
Nov 13, 2019·The Journal of Craniofacial Surgery·Gian Battista BottiniAlexander Gaggl
Sep 29, 2011·Neuroimmunomodulation·Salete SmaniottoWilson Savino
May 4, 2010·Current Opinion in Pharmacology·Wilson Savino, Mireille Dardenne

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