Lymphocyte subset populations in bronchiolitis obliterans after heart-lung transplantation

Transplantation
V A HollandE C Lawrence

Abstract

The long-term success of heart-lung transplantation is limited by the development of bronchiolitis obliterans, possibly as a form of chronic lung allograft rejection. In the present study, we have characterized by immunohistochemical staining the lymphocytes infiltrating the lesions of bronchiolitis obliterans in one patient following heart-lung transplantation. The finding that the preponderant cells expressed the CD8 (putative cytotoxic/suppressor) marker lends support to the notion that chronic rejection is at least one mechanism for the development of bronchiolotis obliterans following heart-lung transplantation.

Citations

Apr 15, 1999·Clinical Transplantation·A H TirokeA Haverich
May 1, 1996·The Pediatric Infectious Disease Journal·J ZahraaD Johnson
Sep 9, 1998·American Journal of Respiratory Cell and Molecular Biology·I P NeuringerR M Aris
Mar 31, 1998·The American Journal of the Medical Sciences·I Paradis
Feb 1, 1997·Human Pathology·S A Yousem
Jun 1, 1997·Clinics in Chest Medicine·K Kelly, M I Hertz

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