Abstract
Removal of the largest single lymphoid organ, the spleen, leads to an increase in severe infections. To prevent this, transplantation of splenic fragments can be performed, which may, however, cause an increase in CD8+ lymphocytes in the blood of these patients. This is controversial since in the clinical situation it is often difficult to account for the different age of the patients, the time point after the operation and many other factors known to influence the number of lymphocyte subsets. Using a well-defined animal model, B, T, CD4+, and CD8+ lymphocytes were determined preoperatively in adult rats. Then, either sham splenectomy, splenectomy, or splenic autotransplantation was performed and the animals were followed up for 15 months after the operation. The surgical procedure itself, the site of blood sampling and ageing all influenced the number of lymphocyte subsets profoundly. Furthermore, giving the data as relative or absolute numbers leads to different results. Splenectomy caused lymphocytosis, due to a significant increase in B and CD8+ lymphocytes, as did splenic autotransplantation, which indicates that the number of lymphocyte subsets in the blood should not be used to argue in favour of or against splenic auto...Continue Reading
References
Mar 1, 1978·Journal of Gerontology·A A MacKinney
Oct 1, 1985·The British Journal of Surgery·T W LennardR M Taylor
Feb 1, 1989·Scandinavian Journal of Immunology·J WestermannR Pabst
Feb 1, 1988·Annals of Surgery·D G BurlesonB A Pruitt
Sep 1, 1988·Journal of Pediatric Surgery·J WestermannR Pabst
Nov 1, 1988·Cell and Tissue Research·J WestermannR Pabst
Jan 1, 1988·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J Westermann, R Pabst
Apr 1, 1988·Sports Medicine·D KeastA R Morton
Apr 1, 1985·The Journal of Trauma·R PabstJ Hillebrand
Feb 1, 1986·Journal of Pediatric Surgery·R Pabst, D Kamran
Sep 1, 1985·Annals of Surgery·M A MalangoniU A Almagro
Jul 20, 1974·Lancet·K J Gajl-PeczalskaE J Yunis
Jun 8, 1974·Lancet·W AugenerG Brittinger
Jun 1, 1974·Klinische Wochenschrift·F Trepel
Sep 16, 1982·The New England Journal of Medicine·H KornfeldM H Grieco
May 1, 1983·American Journal of Surgery·T Sekikawa, C H Shatney
Nov 1, 1983·The American Journal of Medicine·R C WilliamsK A Kilpatrick
Mar 1, 1984·The British Journal of Surgery·M J Cooper, R C Williamson
Feb 1, 1982·Annals of Surgery·J HortonD Coln
Jan 1, 1981·Laboratory Animals·R K Archer, J Riley
Dec 1, 1981·Annals of Surgery·B J O'Neal, J C McDonald
Aug 1, 1952·Annals of Surgery·H KING, H B SHUMACKER
Citations
Sep 1, 1993·Annals of Hematology·A FranchM Castell
May 29, 1996·International Journal of Cancer. Journal International Du Cancer·M S LinetJ F Fraumeni
Oct 16, 1999·British Journal of Haematology·H M WolfR Passl
Jan 21, 2003·Leukemia & Lymphoma·Novica M MilićevićJuergen Westermann
Feb 10, 2020·Journal of Neurology·F SchweitzerC Warnke
Nov 8, 2001·Blood·N M MilićevićJ Westermann
Feb 12, 2004·Scandinavian Journal of Immunology·M KarakantzaA Maniatis
Aug 17, 2001·Developmental Psychobiology·V Stefanski
Oct 11, 2007·Clinical and Experimental Immunology·G L TheodorouM Karakantza
Aug 1, 1996·European Journal of Immunology·J WestermannE B Bell
Dec 1, 1995·Cell and Tissue Research·V BlaschkeJ Westermann
Mar 10, 2001·Journal of Neuroimmunology·V StefanskiS Schulz
Aug 14, 2021·Scientific Reports·Aleksandra E KmieciakEamonn A Gaffney