PMID: 6975746Nov 1, 1981Paper

Lymphocyte surface proteins recognized by an anti-thymocyte-globulin

Hoppe-Seyler's Zeitschrift für physiologische Chemie
W Jilg, K Hannig

Abstract

Rat lymphocyte surface proteins were labelled by lactoperoxidase-catalysed iodination and immunoprecipitated by an anti-thymocyte globulin (ATG). ATG-Reactive proteins from cortical and medullary thymocytes, peripheral T cells and B cells were examined by gel electrophoresis. Several surface molecules were identified which showed differences in their distribution in the four cell populations. A 105 000-Da component was found in relatively high density on thymocytes and peripheral T cells only. Two high-molecular mass components of 205 000 Da and 190 000 Da were observed which were highly specific for peripheral T cells. These molecules appeared to share antigenic determinants with two other proteins found on the surface of both peripheral T cells and thymocytes. Limited proteolysis with Staphylococcus aureus protease showed these four proteins to have a similar peptide composition indicating the existence of a family of related surface molecules with varying expression on different cells. One of these T cell-specific proteins (P 190) was present at a comparatively high density, making up about 4% of the membrane protein. The main protein recognised by ATG was a component with a molecular mass of 175 000 Da found on all lymphocy...Continue Reading

References

Jan 1, 1977·Contemporary Topics in Molecular Immunology·A F Williams
Feb 1, 1975·The Journal of Cell Biology·A L Hubbard, Z A Cohn
Jul 12, 1974·Biochimica Et Biophysica Acta·C T LadoulisT J Gill
Dec 1, 1973·The Journal of Experimental Medicine·I Goldschneider, D D McGregor
Jan 1, 1980·Hoppe-Seyler's Zeitschrift für physiologische Chemie·W JilgK O'Zeiller

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Citations

Jan 9, 2008·Seminars in Hematology·Elaine M Sloand, Katayoun Rezvani
Jun 18, 2016·International Journal of Molecular Sciences·Andreas GlenthøjKirsten Grønbæk

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