Lymphocyte-to-monocyte ratio on day 7 is associated with outcomes in acute ischemic stroke

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Min-Gyu ParkKyung-Pil Park

Abstract

The main features of stroke-induced immunosuppression are lymphopenia and deactivation of monocytes in peripheral blood. We hypothesized that lymphocyte-to-monocyte ratio (LMR) in peripheral blood may represent the degree of stroke-induced immunosuppression. To prove this hypothesis, we evaluated whether LMR is associated with risk of post-stroke infection and clinical outcome at 3 months in patients with acute ischemic stroke. We selected patients with stroke in anterior circulation within 24 h from onset. Peripheral blood sampling for differential blood count was performed on days 1 and 7. The LMRs on days 1 and 7 were analyzed to determine associations with excellent outcomes (modified Rankin Scale of score 0-1 at 3 months). One hundred and two patients were included. The initial National Institutes of Health Stroke Scale score (adjusted odd ratio [OR] 0.89; 95% confidence interval [CI], 0.83-0.95; P = 0.001) and LMR on day 7 (adjusted OR 1.49; 95% CI, 1.09-2.02; P = 0.011) were associated with excellent outcomes. LMRs on day 1 were significantly lower in stroke patients with pneumonia (P = 0.007) and pneumonia or urinary tract infection (P = 0.012) than those without infections. LMRs on day 7 were also significantly lower i...Continue Reading

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Citations

Nov 24, 2019·Irish Journal of Medical Science·Hülya Olgun YazarDursun Kirbaş
Sep 17, 2019·European Journal of Clinical Investigation·Elena Arellano-OrdenRudolph Schutte
Mar 28, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Quhong SongMing Liu
Oct 3, 2018·Journal of Molecular Neuroscience : MN·Lu-Yao AoYun-Man Li
Jul 15, 2020·The Journal of International Medical Research·Huiling LiuYazhou Wang
Oct 31, 2020·Frontiers in Neurology·Hao-Ran ChengZhen Wang
Mar 6, 2021·Frontiers in Neurology·Bowei ZhangXunming Ji
Mar 30, 2021·Neuropsychiatric Disease and Treatment·Kai-Qi DingLi-Li Zeng
Apr 12, 2021·Neurosurgical Review·James FeghaliChristopher M Jackson

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