Lymphocyte traffic through lymph nodes and Peyer's patches of the rat: B- and T-cell-specific migration patterns within the tissue, and their dependence on splenic tissue

Cell and Tissue Research
V BlaschkeJ Westermann

Abstract

The migration routes of lymphocyte subsets through organ compartments are of importance when trying to understand the local events taking place during immune responses. We have therefore studied the traffic of B, T, CD4(+), and CD8(+ )lymphocytes through lymph nodes and Peyer s patches. At various time points after injection into the rat, labeled lymphocytes were localized, and their phenotype characterized in cryostat sections using immunohistochemistry. Morphometry was also performed, and the recovery of 51Cr-labeled lymphocytes in these organs was determined. B and T lymphocytes entered the lymph nodes via the high endothelial venules in similar numbers. Most B lymphocytes migrated via the paracortex (T cell area) into the cortex (B cell area), and then back in substantial numbers into the paracortex. In contrast, T lymphocytes predominantly migrated into the paracortex and were rarely seen in the cortex. No obvious differences were seen between various lymph nodes and Peyer s patches and the routes of CD4(+) and CD8(+)lymphocytes. After injection of lymphocytes into animals with autotransplanted splenic tissue, the number of B lymphocytes that had migrated into the B cell area of lymph nodes and of Peyer s patches was signi...Continue Reading

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Citations

Jan 13, 2001·Springer Seminars in Immunopathology·H YoneyamaK Matsushima
Jun 1, 1996·Immunology Today·J Westermann, R Pabst
Mar 1, 2006·The Journal of Experimental Medicine·Marc BajénoffNicolas Glaichenhaus
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Aug 8, 2014·PLoS Computational Biology·Johannes TextorJoost B Beltman
Jun 29, 2004·Nuclear Medicine and Biology·Alessandro FulgenziMaria Elena Ferrero
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Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ulrike BodeJürgen Westermann

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